April 2017

2017 OARSI World Congress on Osteoarthritis
Promoting Clinical and Basic Research in Osteoarthritis
Published in issue: April 2017
iii

OARSI Board of Directors
Published in issue: April 2017
iv

2017 OARSI World Congress Program Planning Committee
Published in issue: April 2017
v

2017 OARSI World Congress Program
Published in issue: April 2017
vi-xvi

Abstracts from Invited Speakers

Clinical update in hand OA
• I.K. Haugen
Published in issue: April 2017
S1
Is Retinoic acid a target in hand osteoarthritis?
• H. Jonsson
Published in issue: April 2017
S1
All You Need to Know About the Microbiome!
• L.J. Hall
Published in issue: April 2017
S1
OA for Beginners
• M.C. Hochberg
Published in issue: April 2017
S1
In Vivo Models of Cartilage Repair and Chondrogenesis
• F. Dell'Accio
Published in issue: April 2017
S1-S2
Engineering TIMP-3 for OA therapy
• L. Troeberg
Published in issue: April 2017
S2
Biomechanical plasticity in locomotion with age, obesity and OA
• P. DeVita
Published in issue: April 2017
S2

Meta-research: A bird’s eye view of OA
• R. Christensen
Published in issue: April 2017
S2-S3
Enhancing the Value of Pre-clinical Studies
• M. Macleod
Published in issue: April 2017
S3
Molecular Targets Arising from GWAS
• R.J.U. Lories
Published in issue: April 2017
S3

Hydroxychloroquine in hand OA; Results of the UK hero trial
• S.R. Kingsbury,
• P. Tharmanathan,
• A. Keding,
• ...
• T. Sheeran,
• D. Torgerson,
• P.G. Conaghan
Published in issue: April 2017
S3-S4
Non-Pharmacological management of osteoarthritis
• G.A. Hawker,
• D. White,
• S.T. Skou
Published in issue: April 2017
S4
Radiographic Predictors of OA progression
• F.W. Roemer
Published in issue: April 2017
S4
Redox regulation of cell signaling in chondrocytes
• R. Loeser
Published in issue: April 2017
S4-S5
Joint Health Begins in Childhood
• G. Jones
Published in issue: April 2017
S5
Type II Collagen; Designed to Last a Lifetime?
• K.M. Heinemeier
Published in issue: April 2017
S5
Effectiveness of surgery: Perception versus reality
• I. Harris
Published in issue: April 2017
S5
Role of Sik3 in pathology of osteoarthritis in mice
• N. Tsumaki
Published in issue: April 2017
S5-S6
Metabolic OA; Does it Exist?
• D. Felson
Published in issue: April 2017
S6
Clinical Testing in Veterinary OA
• P.D. Hanson
Published in issue: April 2017
S6
MRI in OA research and the clinic
• E. Oei
Published in issue: April 2017
S6-S7
Year in Review – Rehabilitation and Outcomes
• D. Schiphof,
• J.J. van den Driest,
• J. Runhaar
Published in issue: April 2017
S7
Year in Review – Osteoarthritis Biology
• T. Appleton
Published in issue: April 2017
S7
Year In Review – Clinical
• A.E. Nelson
Published in issue: April 2017
S7
Year In Review – Genetics/Genomics and Epigenetics
• M.J. Peffers
Published in issue: April 2017
S7
Year in Review – Biomarkers
• F.E. Watt
Published in issue: April 2017
S7
Year in Review - Mechanics
• Y. Wang
Published in issue: April 2017
S7

Oral Presentations

Randomised, placebo-controlled trial to evaluate clinical efficacy and structure modifying properties of subcutaneous etanercept in patients with erosive inflammatory hand osteoarthritis
• M. Kloppenburg,
• R. Ramonda,
• W.-Y. Kwok,
• ...
• L. Punzi,
• G. Verbruggen,
• R. Wittoek
Published in issue: April 2017
S8
Functional characterisation of the osteoarthritis genetic risk locus that resides at the gene ALDH1A2, coding for the retinoic acid synthesis enzyme RALDH2, identifies rs4646636 and rs12915901 as key target SNPs
• C. Shepherd,
• D. Zhu,
• A.J. Skelton,
• J. Combe,
• L.N. Reynard,
• J. Loughlin
Published in issue: April 2017
S9

A randomised double-blind placebo-controlled crossover trial of humira (adalimumab) for erosive hand osteoarthritis: the humor trial
• D. Aitken,
• F. Pan,
• L. Laslett,
• ...
• P. Bird,
• I. Haugen,
• G. Jones
Published in issue: April 2017
S9
The role of the gut microbiome in osteoarthritis and joint pain
• C.G. Boer,
• D. Radjabzadeh,
• A.G. Uitterlinden,
• R. Kraaij,
• J.B. van Meurs
Published in issue: April 2017
S10

Multiple injections of platelet rich plasma releasate reduce pain and synovial thickening in a mice osteoarthritis model
• S. Khatab,
• G.M. van Buul,
• P.K. Bos,
• J.A. Verhaar,
• G.J. van Osch
Published in issue: April 2017
S10-S11

Prebiotic manipulation of the gut microbiome with oligofructose confers protection against the osteoarthritis of obesity
• E. Schott,
• C. Farnsworth,
• A. Grier,
• ...
• S. Gill,
• R. Mooney,
• M. Zuscik
Published in issue: April 2017
S11-S12

Prediction of risk for radiographic hip osteoarthritis in subjects with early osteoarthritis of hip or knee
• W.P. Gielis,
• H.H. Weinans,
• W.E. van Spil,
• ...
• T.F. Cootes,
• P.A. de Jong,
• C. Lindner
Published in issue: April 2017
S12
Chondrocyte PTH1R anti-hypertrophic signaling is essential for articular cartilage maintenance and protection post trauma
• F. Kamal,
• E.M. Schott,
• E.L. Carlson,
• ...
• M.J. Hilton,
• J.H. Jonason,
• M.J. Zuscik
Published in issue: April 2017
S13-S14

Knocking out or pharmaceutical inhibition of fatty acid binding protein 4 (Fabp-4) alleviates osteoarthritis induced by a very high fat diet in mouse
• C. Zhang,
• C. Yan,
• A. Xu,
• B. Chan,
• K. Chiu
Published in issue: April 2017
S14

Systemic antagonism of toll-like receptor 4 reduces post-traumatic osteoarthritis in a murine model
• K.S. Santangelo
Published in issue: April 2017
S14-S15

Exercise-induced pain reductions in knee osteoarthritis are associated with changes in muscle perfusion quantified by dynamic contrast enhanced magnetic resonance imaging: exploratory outcome analysis from a randomized controlled trial
• E. Bandak,
• M. Boesen,
• H. Bliddal,
• ...
• C. Bartholdy,
• J.D. Nybing,
• M. Henriksen
Published in issue: April 2017
S15
Zcchc6 and Zcchc11 exhibit cell autonomous effects on bone remodeling in mice
• G. Sondag,
• S. Haynie,
• F.F. Safadi,
• T.M. Haqqi
Published in issue: April 2017
S16-S17
Postnatal influence of the ciliome in the joint
• C.R. Coveney,
• I. Collins,
• M. McFie,
• A. Chanalaris,
• T.L. Vincent,
• A.K. Wann
Published in issue: April 2017
S17
Connective tissue growth factor determines cartilage thickness and osteoarthritic risk by controlling activation of latent transforming growth factor beta in cartilage
• X. Tang,
• J. Zarebska,
• M. Curtinha,
• B. Stott,
• T. Vincent
Published in issue: April 2017
S17

14-3-3 epsilon is a novel component of PGRN/TNFR2 complex to mediate pgrn's protective role in chondrocytes and osteoarthritis
• W. Fu,
• Y.-S. Yi,
• C.-J. Liu
Published in issue: April 2017
S17-S19
The role of transient receptor potential cation channel trpc6 activity in cxcr2-mediated chondrocyte phenotypic stability
• J. Sherwood,
• J. Bertrand,
• F. Dell'Accio,
• T. Pap
Published in issue: April 2017
S19
Role of SUMOylation in primary osteoarthritis pathogenesis
• A. Moreau,
• M. Taheri,
• M. Pellicelli,
• ...
• P. Lavigne,
• K.F. Gorman,
• A. Franco
Published in issue: April 2017
S19-S20
Therapeutic targeting of GPCR gbetagamma-GRK2 signaling in osteoarthritis
• E.L. Carlson,
• E.M. Schott,
• M. El-Quadi,
• ...
• R. Elbarbary,
• M.J. Zuscik,
• F. Kamal
Published in issue: April 2017
S20
Features of gait mechanics and biology that predict cartilage thickness change in a population at risk for age-related knee osteoarthritis
• E.F. Chehab,
• J.L. Asay,
• J. Favre,
• T.P. Andriacchi
Published in issue: April 2017
S20-S21