Summary
Objective
To summarize changes in recommendations for injection treatments for knee osteoarthritis
(OA) in current clinical practice guidelines (CPGs) and to assess whether these changes
have affected public interest according to Google data and content in YouTube videos.
Design
A literature search to identify CPGs revised since 2019 that provide recommendations
regarding the five intra-articular injection treatments for knee OA (corticosteroid
[CS], hyaluronic acid [HA], stem cell [SC], platelet-rich plasma [PRP], and botulinum
toxin [BT]) was conducted to assess perspective changes for each treatment. Data from
Google Trends were examined to identify changes in search volume from 2004 to 2021
using a join-point regression model. Relevant YouTube videos were divided into those
uploaded before and after changes in CPGs and compared according to degrees of recommendation
for each treatment to identify the effect of changes in CPGs on video production.
Results
All eight identified CPGs released after 2019 recommended HA and CS use. Most CPGs
were the first to state a neutral or opposing stance concerning the use of SC, PRP,
or BT. Interestingly, relative searches on Google for SC, PRP, and BT has increased
greater than those for CS and HA. YouTube videos produced after CPGs changed continue
to recommend SC, PRP, and BT as much as those produced before CPGs were revised.
Conclusions
Although knee OA CPGs have changed, public interest and healthcare information providers
on YouTube have not reacted to this shift. Improved methods to propagate updates to
CPGs warrant consideration.
Keywords
Abbreviations:
AAPC (average annual percentage change), APC (annual percentage change), ARSV (annual relative search volume), BT (botulinum toxin), CPGs (clinical practice guidelines), CS (corticosteroid), HA (hyaluronic acid), IA (intra-articular), OA (osteoarthritis), PRP (platelet-rich plasma), RSV (relative search volume), SC (stem cell)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: February 20, 2023
Accepted:
December 20,
2022
Received:
July 8,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
