Summary
Objective
There is continued debate as to how engaging in physical activity (PA), including
moderate-to-vigorous PA (MVPA), light PA (LPA), and sedentary time (SED), affects
one's risk for knee osteoarthritis (OA). Traditional regression methods do not account
for the codependence of these categories of PA, whereby when one category increases,
the others must decrease. Thus, we used compositional data analysis (CoDA) to examine
time spent in each category of PA, or PA composition, and its association with loss
of knee joint space width (JSW), a common indicator of knee OA progression.
Methods
We performed a secondary analysis of data from a subset of participants in the Osteoarthritis
Initiative. These participants had minute-by-minute activity data collected over 7
days at baseline; we then categorized each minute as MVPA, LPA, or SED. Our exposure,
PA composition, represented min/day spent in each category. Our outcome, medial JSW
loss, was the difference in medial tibiofemoral JSW from baseline to 2 years later.
We employed CoDA, using an isometric log-ratio transformation, to examine the association
of PA composition with medial JSW loss over 2 years, adjusting for potential confounders.
Results
We included 969 participants (age: 64.5 years, 56% female, body mass index [BMI]:
28.8 kg/m2). Mean PA composition was: MVPA 9.1 min/day, LPA 278 min/day, SED 690 min/day. Per
adjusted regression models, higher MVPA was not associated with greater medial JSW
loss (β = −0.0005, P = 0.97), nor was LPA (β = 0.06, P = 0.27) or SED (β = −0.06, P = 0.21).
Conclusion
Using CoDA, PA composition was not associated with medial JSW loss over 2 years.
Keywords
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Article info
Publication history
Published online: February 21, 2023
Accepted:
December 15,
2022
Received:
July 1,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.
