Summary
Objective
To examine the association between 3D patellar shape and 1) isolated magnetic resonance
imaging (MRI)-based patellofemoral osteoarthritis (PFOA), 2) the morphological features
of PFOA, and 3) the clinical symptoms of PFOA.
Design
MRI data from 66 women with isolated MRI-based PFOA and 66 age- and BMI-matched healthy
women were selected from a cohort study. The patellae were manually segmented from
MRI scans and used to create a 3D statistical shape model (SSM) of the patella. Structural
abnormalities were semi-standardized scored on MRI using MRI osteoarthritis knee score
(MOAKS). Regression analyses were applied to determine the associations between the
shape parameters retrieved from the SSM, group status, clinical symptoms, and structural
abnormalities.
Results
Four shape variants showed a statistically significant (<0.05) association with the
group status. The mode responsible for most of the shape variations showed participants
with PFOA possess a relatively thicker dorsal bump on the articular part of the patella,
compared to patellae of control participants. Three of these variants showed an association
with the presence of osteophytes and cartilage loss on the patella. Multiple associations
were found between patellar shape and the clinical symptoms of PFOA.
Conclusions
Patellar shape is associated with the prevalence of MRI-based PFOA in women. Some
shape variants were also associated with clinical symptoms. Interestingly, one particular
shape variant associated with the presence of MRI-based PFOA was earlier shown to
be associated with structural abnormalities associated with OA in a population aged
under 40. This may suggest that patellar shape may be an early detectable risk factor
for PFOA.
Keywords
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Article info
Publication history
Published online: January 06, 2023
Accepted:
December 20,
2022
Received:
June 6,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.
