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How can recombinant adeno-associated virus (rAAV) vector technology be empowered with biofabrication strategies in its translation towards the clinic?

Published:December 14, 2022DOI:https://doi.org/10.1016/j.joca.2022.12.005
      Available treatment options for osteoarthritis (OA), including regenerative approaches, are currently unable to restore long-term functionality of the joint. This, combined with the expected increase in prevalence of OA and the concomitant rising socioeconomic burden, makes the need for novel strategies for functional tissue restoration highly urgent
      • Hiligsmann M.
      • Cooper C.
      • Arden N.
      • Boers M.
      • Branco J.C.
      • Luisa Brandi M.
      • et al.
      Health economics in the field of osteoarthritis: an expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).
      . One of the most common precursors of OA is damaged articular cartilage. Key to the successful, long-term restoration of joint function by any such strategy is reestablishment of the biological and biomechanical functionality of neocartilage, and its integration with the adjacent native tissues. Furthermore, cell hypertrophy, as well as perifocal OA, should be prevented, and subchondral bone should remain in a healthy condition
      • Goldring M.B.
      Articular cartilage degradation in osteoarthritis.
      ,
      • Kijowski R.
      • Demehri S.
      • Roemer F.
      • Guermazi A.
      Osteoarthritis year in review 2019: imaging.
      . These requirements therefore demand a strategy that encompasses both structural organization and biological maturation of the neo-tissue.
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