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Editorial| Volume 31, ISSUE 4, P421-422, April 2023

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How can recombinant adeno-associated virus (rAAV) vector technology be empowered with biofabrication strategies in its translation towards the clinic?

Published:December 14, 2022DOI:https://doi.org/10.1016/j.joca.2022.12.005
How can recombinant adeno-associated virus (rAAV) vector technology be empowered with biofabrication strategies in its translation towards the clinic?
Next ArticleOsteoarthritis and comorbidity: time for action
      Available treatment options for osteoarthritis (OA), including regenerative approaches, are currently unable to restore long-term functionality of the joint. This, combined with the expected increase in prevalence of OA and the concomitant rising socioeconomic burden, makes the need for novel strategies for functional tissue restoration highly urgent
      • Hiligsmann M.
      • Cooper C.
      • Arden N.
      • Boers M.
      • Branco J.C.
      • Luisa Brandi M.
      • et al.
      Health economics in the field of osteoarthritis: an expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).
      Semin Arthritis Rheum. 2013; 43 (Epub Aug 29, 2013. PMID: 23992801): 303-313https://doi.org/10.1016/j.semarthrit.2013.07.003
      . One of the most common precursors of OA is damaged articular cartilage. Key to the successful, long-term restoration of joint function by any such strategy is reestablishment of the biological and biomechanical functionality of neocartilage, and its integration with the adjacent native tissues. Furthermore, cell hypertrophy, as well as perifocal OA, should be prevented, and subchondral bone should remain in a healthy condition
      • Goldring M.B.
      Articular cartilage degradation in osteoarthritis.
      HSS J. 2012; 8: 7-9
      ,
      • Kijowski R.
      • Demehri S.
      • Roemer F.
      • Guermazi A.
      Osteoarthritis year in review 2019: imaging.
      Osteoarthritis Cartilage. 2020; 28 (Epub Dec 23, 2019. PMID: 31877380): 285-295https://doi.org/10.1016/j.joca.2019.11.009
      . These requirements therefore demand a strategy that encompasses both structural organization and biological maturation of the neo-tissue.
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      Article info

      Publication history

      Published online: December 14, 2022
      Accepted: December 8, 2022
      Received: November 29, 2022

      Identification

      DOI: https://doi.org/10.1016/j.joca.2022.12.005

      Copyright

      © 2022 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

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