Reducing the prevalence of overweight and obesity has been a primary focus in the
management and prevention of chronic disease, including diabetes, cancer, and knee
osteoarthritis (OA)
1
,2
. Specific to knee OA, obesity can accelerate disease progression and contribute to
disability. Consequently, a 5–10% weight loss combined with exercise is among the
most prescribed and effective non-surgical treatments for knee OA, recommended as
part of best practice by several international guidelines and resulting in important
clinical and mechanistic outcomes, including reductions in pain and improvements in
function and health-related quality of life.To read this article in full you will need to make a payment
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References
- The epidemiology of obesity.Metabolism. 2019; 92: 6-10
- Obesity as a disease: the obesity society 2018 position statement.Obesity. 2019; 27: 7-9
- Association of weight gain with incident knee pain, stiffness, and functional difficulties: a longitudinal study.Arthritis Care Res. 2013; 65: 34-43
- Weight change and change in tibial cartilage volume and symptoms in obese adults.Ann Rheum Dis. 2015; 74: 1024-1029
- Body weight changes and corresponding changes in pain and function in persons with symptomatic knee osteoarthritis. A cohort study: body weight changes and corresponding changes in pain and function.Arthritis Care Res. 2013; 65: 15
- Obesity: preventing and managing the global epidemic. Report of a WHO consultation.World Health Organ Tech Rep Ser. 2000; 894 (1–253): i-xii
- Long-term weight-loss maintenance in obese patients with knee osteoarthritis: a randomized trial.Am J Clin Nutr. 2017; 158543
- Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial.JAMA. 2013; 310: 1263-1273
- Influence of context effects on health outcomes: a systematic review.Lancet. 2001; 357: 757-762
- The ‘placebo’ response in osteoarthritis and its implications for clinical practice.Osteoarthr Cartil. 2009; 17: 1255-1262
- Clinical relevance of contextual factors as triggers of placebo and nocebo effects in musculoskeletal pain.BMC Musculoskelet Disord. 2018; 19: 27
- Identifying patient strengths instruments and examining their relevance for chronic disease management: a systematic review.Prev Chronic Dis. 2021; 18: E41
- Association between weight gain and knee osteoarthritis: a systematic review.Osteoarthr Cartil. 2022;
Article info
Publication history
Published online: December 02, 2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
