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Cholesterol, systemic inflammation, interleukin-1B, and osteoarthritis risk — aligning animal models with specific patient endotypes provides novel insights

  • C.B. Little
    Affiliations
    Raymond Purves Bone and Joint Research Laboratory, Kolling Institute, Institute of Bone and Joint Research, Faculty of Medicine and Health, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
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Published:December 02, 2022DOI:https://doi.org/10.1016/j.joca.2022.11.009
      Among the many risk factors for osteoarthritis (OA), obesity and metabolic syndrome (MetS) are increasing in importance with societal escalation in sedentary lifestyles and consumption of unhealthy Western diets
      • Urban H.
      • Little C.B.
      The role of fat and inflammation in the pathogenesis and management of osteoarthritis.
      ,
      • Batushansky A.
      • Zhu S.
      • Komaravolu R.K.
      • South S.
      • Mehta-D'souza P.
      • Griffin T.M.
      Fundamentals of OA. An initiative of Osteoarthritis and Cartilage. Obesity and metabolic factors in OA.
      . There is a bidirectional relationship between obesity/MetS and OA
      • Liu S.Y.
      • Zhu W.T.
      • Chen B.W.
      • Chen Y.H.
      • Ni G.X.
      Bidirectional association between metabolic syndrome and osteoarthritis: a meta-analysis of observational studies.
      , while the increased OA risk associated with obesity/MetS can also be transmitted intergenerationally through epigenetic modification
      • Harasymowicz N.S.
      • Choi Y.R.
      • Wu C.L.
      • Iannucci L.
      • Tang R.
      • Guilak F.
      Intergenerational transmission of diet-induced obesity, metabolic imbalance, and osteoarthritis in mice.
      .
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