Summary
Objectives
The aim of this systematic review was to assess the effects of stem cell-based therapies
on the treatment of Temporomandibular Joint Osteoarthritis (TMJ-OA) and the regeneration
of cartilage/osteochondral defects.
Methods
Data on preclinical studies evaluating the effectiveness of stem cell-based therapies
for treating Temporomandibular Disorders (TMDs) were extracted from PubMed, Web of
Science, and Cochrane Library and the grey literature by three independent reviewers.
A manual search was performed in the databases, the reference list of review studies,
and relevant journals in the field. Compliance with the ARRIVE guidelines was evaluated
for quality assessment. SYRCLE's risk of bias tool for animal experimental studies
was assessed to define internal validity.
Results
After applying the inclusion and exclusion criteria, 10 studies were included in the
qualitative synthesis. Regardless of cell origin, stem cell-based therapeutic approaches
induced protective, anti-inflammatory, and chondroregenerative potential in the treatment
of TMJ-OA. Regeneration of the cartilage layer on the surface of the condyle was achieved
when stem cells were directly flushed into the defect or when delivered within a carrier.
Conclusion
Stem cell-based therapies may be considered a promising approach for the treatment
of TMJ-OA and for the regeneration of full-thickness cartilage and osteochondral defects
in the TMJ. Human studies shall be performed to validate these results found in animals.
Keywords
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Article info
Publication history
Published online: May 17, 2022
Accepted:
May 10,
2022
Received:
December 8,
2021
Identification
Copyright
© 2022 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
