Purpose: Prevention of osteoarthritis remains important as there are no disease-modifying
treatments. A personalized approach has the potential to better target prevention
strategies. We used recently identified genetic risk variants from genome-wide association
analysis for advanced osteoarthritis to calculate polygenic risk scores (PRSs) for
knee and hip osteoarthritis, and assessed PRS performance in an independent population
of older community-dwelling adults.
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© 2022 Published by Elsevier Inc.
