Summary
Osteoarthritis (OA) is a heterogeneous disorder. The goals of this review are (1)
To stimulate use of standardized nomenclature for OA that could serve as building
blocks for describing OA and defining OA phenotypes, in short to provide unifying
disease concepts for a heterogeneous disorder; and (2) To stimulate establishment
of ROAD (Risk of OA Development) and ROAP (Risk of OA Progression) tools analogous
to the FRAX™ instrument for predicting risk of fracture in osteoporosis; and (3) To
stimulate formulation of tools for identifying disease in its early preradiographic
and/or molecular stages – REDI (Reliable Early Disease Identification). Consensus
around more sensitive and specific diagnostic criteria for OA could spur development
of disease modifying therapies for this entity that has proved so recalcitrant to
date. We fully acknowledge that as we move forward, we expect to develop more sophisticated
definitions, terminology and tools.
Keywords
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Article info
Publication history
Published online: April 09, 2015
Accepted:
March 31,
2015
Received:
December 6,
2014
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© 2015 Osteoarthritis Research Society International. Published by Elsevier Inc. All rights reserved.
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