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2015 OARSI World Congress FINAL PROGRAM

        Tabled 1
        Thursday April 30, 2015
        9:00 AM – 12:00 PM

        Ballroom 6 B
        Congress Workshop

        Update on the FNIH Osteoarthritis Biomarkers Consortium Project

        Virginia Byers Kraus, MD, PhD

        Jamie E. Collins, PhD

        David J. Hunter, PhD, FRACP

        Elena Losina, PhD

        Michael Nevitt, PhD, MPH
        10:00 AM – 12:00 PM

        Ballroom 6 A
        Congress Workshop for Young Investigators

        Common Statistical Issues in OA Research

        Moderators:

        Felix Eckstein, MD
        Panelists:

        Robert Buck, PhD

        Yu-Mei Ruby Chang, PhD, CStat

        Jonas Ranstam, BSc, PhD, CStat, CSci
        Thursday April 30, 2015
        1:00 PM – 2:30 PM

        Ballroom 6 AB
        Welcome Plenary Session 1

        Joint Lubrication: Facts or Friction?

        Moderators:

        Martin Englund, MD, PhD

        Tonia Vincent, FRCP, PhD
        1:00 PM – 1:30 PMJoint Lubrication: How Does Nature Do It?

        Jacob Klein, PhD
        1:30 PM – 2:00 PMLubricin and its Potential as an OA Therapy

        Carl Flannery, PhD
        2:00 PM – 2:10 PM
        1
        LUBRICIN AND HOW ITS CARBOHYDRATE-PROTEIN AND PROTEIN-PROTEIN INTERACTIONS PROVIDE ITS FUNTIONALLITY
        N. G. Karlsson, S. A. Flowers, L. Ali, C. Jin; Univ. of Gothenburg, Gothenburg, Sweden
        2:10 PM – 2:20 PM
        2
        LUBRICATION OF CARTILAGE – MENISCUS BIOINTERFACE BY PROTEOGLYCAN 4 AND HYALURONAN; EFFECT OF SLIDING VELOCITY
        S. Dorosz, T. Schmidt; Univ. of Calgary, Calgary, AB, Canada
        2:20 PM – 2:30 PM
        3
        SUB-CRITICAL IMPACT INHIBITS CARTILAGE LUBRICATION MECHANISMS
        Tabled 1
        2:30 PM – 3:00 PMBREAK
        3:00 PM – 4:30 PM

        Ballroom 6 A
        Concurrent Session 1:

        Health Services and Epidemiology in OA

        Moderators:

        Ida Haugen, MD, PhD

        Stephen P. Messier, PhD
        3:00 PM – 3:30 PMImpact of Knee OA on Meeting Physical Activity Guidelines

        Daniel White, PT, ScD, MSc
        3:30 PM – 3:40 PM
        4
        ASSOCIATION OF BREAKS IN SEDENTARY TIME WITH PHYSICAL FUNCTIONAL LOSS IN OSTEOARTHRITIS INITIATIVE
        J. Lee1, J. Song1, R. W. Chang1,2, P. A. Semanik3, L. S. Ehrlich-Jones1,2, C. A. Pellegrini1, D. Pinto1, D. Dunlop1; 1Northwestern Univ., Chicago, IL, 2Rehabilitation Inst. of Chicago, Chicago, IL, 3Rush Univ., Chicago, IL
        3:40 PM – 3:50 PM
        5
        PHYSICAL ACTIVITY AND QUALITY OF LIFE RELATE TO CHANGES IN COLLAGEN TURNOVER AND INFLAMMATION AFTER A RUNNING BOUT
        N. M. Cattano1, J. B. Driban2, M. F. Barbe3, M. Amin3, R. Tierney3, M. R. Sitler3; 1West Chester Univ., West Chester, PA, 2Tufts Univ., Boston, MA, 3Temple Univ., Philadelphia, PA
        3:50 PM – 4:00 PM
        6
        HABITUAL RUNNING DOES NOT INCREASE RISK FOR SYMPTOM OR STRUCTURE PROGRESSION IN THOSE WITH PRE-EXISTING KNEE OSTEOARTHRITIS: DATA FROM THE OSTEOARTHRITIS INITIATIVE
        G. H. Lo1, J. B. Driban2, A. M. Kriska3, K. L. Storti4, T. E. McAlindon2, R. B. Souza5, C. B. Eaton6, M. C. Hochberg7, R. D. Jackson8, C. K. Kwoh9, M. C. Nevitt5, N. J. Petersen1, M. E. Suarez-Almazor10; 1Baylor Coll. of Med., Houston, TX, 2Tufts Med. Ctr., Boston, MA, 3Univ. of Pittsburgh, Pittsburgh, PA, 4Indiana Univ. of Pennsylvania, Indiana, PA, 5Univ. of California San Francisco, San Francisco, CA, 6Mem. Hosp. of Rhode Island, Pawtucket, RI, 7Univ. of Maryland, Baltimore, MD, 8The Ohio State Univ., Columbus, OH, 9Univ. of Arizona, Tuscon, AZ, 10The Univ. of Texas, MD Anderson Cancer Ctr., Houston, TX
        4:00 PM – 4:10 PM
        7
        BARRIERS AND FACILITATORS TO EXERCISE PARTICIPATION IN PEOPLE WITH HIP AND/OR KNEE OSTEOARTHRITIS
        P. J. Nicolson1, F. L. Dobson1, K. L. Bennell1, S. D. French2, R. N. Klassmann3, M. A. Holden4, R. S. Hinman1; 1Ctr. for Hlth., Exercise and Sports Med., Univ. of Melbourne, Melbourne, Australia, 2Sch. of Rehabilitation Therapy, Queen's Univ., Kingston, ON, Canada, 3Faculty of Hlth.care, Univ. of Applied Sci. Utrecht, Utrecht, Netherlands, 4Arthritis Res. UK Primary Care Ctr., Keele Univ., Keele, United Kingdom
        4:10 PM – 4:20 PM
        8
        IMPLEMENTING OSTEOARTHRITIS GUIDELINES IN UK PRIMARY CARE: MOSAICS CLUSTER RANDOMISED CONTROLLED TRIAL
        K. Dziedzic, The MOSAICS Study group; Keele Univ., Keele, United Kingdom
        4:20 PM – 4:30 PM
        9
        COST-EFFECTIVENESS ANALYSIS OF ARTHROSCOPIC SURGERY COMPARED TO NON-OPERATIVE MANAGEMENT FOR OSTEOARTHRITIS OF THE KNEE
        Tabled 1
        3:00 PM – 4:30 PM

        Ballroom 6 B
        Concurrent Session 2:

        Aging Moderators:

        Anna Plaas, PhD

        Peter van der Kraan, PhD
        3:00 PM – 3:30 PMThe Aging Process and Epigenetics: Relationship with OA

        Louise Reynard, PhD
        3:30 PM – 3:40 PM
        10
        SUPPRESSION OF REDD1 IN OA CARTILAGE, A NOVEL MECHANISM FOR DYSREGULATED MTOR ACTIVATION
        O. Alvarez-Garcia, R. Akagi, Y. Akasaki, K. M. Fisch, A. I. Su, M. K. Lotz; The Scripps Res. Inst., La Jolla, CA
        3:40 PM – 3:50 PM
        11
        THE HARWELL AGEING SCREEN: A DISCOVERY PLATFORM FOR GENES AND PATHWAYS ASSOCIATED WITH AGE-RELATED DISEASE
        A. Blease1, M. E. Goldsworthy1, A. Haynes1, L. Wisby1, T. Nicol1, S. Falcone1, H. Lad1, T. Vincent2, S. D. Brown1, P. K. Potter1; 1Mammalian Genetics Unit, MRC Harwell, United Kingdom, 2ARUK Ctr. for OA Pathogenesis, Kennedy Institute of Rheumatology, United Kingdom
        3:50 PM – 4:00 PM
        12
        COMPREHENSIVE TRANSCRIPTOME ANALYSIS OF AGING-RELATED GENE EXPRESSION IN EARLY PHASE OF POST-TRAUMATIC OSTEOARTHRITIS
        T. Fukui1, A. B. Castillo2, J. H. Yik1, D. R. Haudenschild1; 1Lawrence J. Ellison Musculoskeletal Res. Ctr., Sacramento, CA, 2Dept. of Mechanical and Aerospace Engineering, New York Univ., New York, NY
        4:00 PM – 4:10 PM
        13
        MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) PROMOTE HYPEROXIDATION OF PEROXIREDOXINS AND INHIBIT PRO-SURVIVAL IGF-1 SIGNALING IN HUMAN ARTICULAR CHONDROCYTES
        J. A. Collins1, L. Poole2, C. Furdui2, K. Nelson2, R. Loeser1; 1Univ. of North Carolina at Chapel Hill, Chapel Hill, NC, 2Wake Forest Sch. of Med., Winston-Salem, NC
        4:10 PM – 4:20 PM
        14
        THE TISSUE SPECIFIC ROLE OF SIRT1 IN JOINT INFLAMMATION AND ANABOLIC CARTILAGE GENE EXPRESSION
        P. K. Sacitharan1, J. Zarebska1, A. Chanalaris1, G. Bou Gharios2, E. J1, T. L. Vincent1; 1Univ. of Oxford, London, United Kingdom, 2Univ. of Liverpool, London, United Kingdom
        4:20 PM – 4:30 PM
        15
        DEFICIENT AUTOPHAGY INDUCES PREMATURE SENESCENCE IN AGING AND OSTEOARTHRITIS
        Tabled 1
        4:30 PM – 5:00 PMBREAK
        5:00 PM – 7:15 PM

        Ballroom 6 AB
        Plenary Session 2: OARSI: 25th Anniversary

        Moderators:

        Virginia Byers Kraus, MD, PhD

        John Loughlin, PhD
        Opening Ceremony/Lifetime Achievement Recognition, Basic and Clinical Award Presentations
        5:00 PM – 5:45 PMPresidential Address & Business Meeting
        5:45 PM – 5:50 PMRecognition of Young Investigators
        5:50 PM – 6:00 PMRecognition of Lifetime Achievement Award Winners

        David R. Eyre, PhD

        George Nuki, MB, FRCP
        6:00 PM – 6:20 PMBasic Science Award Winner Presentation

        Unraveling the Complexity of Signaling and Gene Expression in Cartilage Degradation

        Mary Goldring, PhD
        6:20 PM – 6:40 PMClinical Science Award Winner Presentation

        Osteoarthritis Research in General Practice

        Sita Bierma-Zeinstra, PhD
        6:45 PM – 7:15 PMHighlights in OA Research Over the Past 25 Years

        Marc Hochberg, MD, MPH
        7:30 PM – 9:00 PMOPENING RECEPTION WITH EXHIBITORS
        Tabled 1
        Friday, May 1, 2015
        7:30 AM – 8.30 AM

        Room 612
        Breakfast Workshop A

        Update on Crystals and OA

        Ann Rosenthal, MD, FACP
        7:30 AM – 8.30 AM

        Room 613 – 614
        Breakfast Workshop B

        Cytokine Crosstalk in Inflammatory and Mechanical Stress Mechanism in Osteoarthritis

        Mary B. Goldring, PhD
        9:00 AM – 10:30 AM

        Ballroom 6 A
        Concurrent Session 3:

        OA therapy

        Moderators:

        Rolando Espinosa Morales, MD, MSc

        Jian Hao Lin, MD
        9:00 AM – 9:30 AMPlacebo Response: Its Role in OA Research and Clinical Practice

        Paul Dieppe, MD
        9:30 AM – 9:40 AM
        16
        EVALUATION OF THE BENEFIT OF CORTICOSTEROID INJECTION PRIOR TO EXERCISE THERAPY IN PATIENTS WITH KNEE OSTEOARTHRITIS: A RANDOMIZED TRIAL
        M. Henriksen, R. Christensen, L. Klokker, C. Bartholdy, K. Ellegaard, M. Boesen, R. Riis, E. Bartels, H. Bliddal; The Parker Inst., Copenhagen, Denmark
        9:40 AM – 9:50 AM
        17
        THE COMBINED EFFICACY OF MULTIMODAL NON-SURGICAL TREATMENT ON PAIN AND SENSITIZATION IN PATIENTS WITH KNEE OSTEOARTHRITIS NOT ELIGIBLE FOR A TOTAL KNEE ARTHROPLASTY – AN ANCILLARY ANALYSIS FROM A RANDOMIZED CONTROLLED TRIAL
        S. T. Skou1,2, E. Roos2, O. Simonsen1, M. B. Laursen1, M. S. Rathleff3, L. Arendt-Nielsen3, S. Rasmussen1; 1Aalborg Univ. Hosp., Aalborg, Denmark, 2Univ. of Southern Denmark, Odense, Denmark, 3Aalborg Univ., Aalborg, Denmark
        9:50 AM – 10:00 AM
        18
        MRI STRUCTURAL PARAMETERS PREDICT SHORT TERM RESPONSE TO INTRA-ARTICULAR STEROID THERAPY IN KNEE OA
        N. Maricar1, M. J. Parkes1, D. T. Felson2, T. F. Cootes1, A. D. Gait1, E. J. Marjanovic1, D. Bailey3, C. E. Hutchinson3, T. W. O'Neill1; 1The Univ. of Manchester, Manchester, United Kingdom, 2Boston Univ., Boston, MA, 3The Univ. of Warwick, Coventry, United Kingdom
        10:00 AM – 10:10 AM
        19
        SUPERVISED NEUROMUSCULAR EXERCISE PRIOR TO HIP OR KNEE REPLACEMENT: COST-UTILITY ANALYSIS ALONGSIDE A RANDOMISED CONTROLLED TRIAL
        L. Fernandes1,2, E. M. Roos3, S. Overgaard1, A. Villadsen1, R. Soegaard4; 1Odense Univ. Hosp., Odense C, Denmark, 2Univ. of Southern Denmark, Clinical Inst., Odense, Denmark, 3Univ. of Southern Denmark, Inst. of Sports Sci. and Clinical Biomechanics, FOF, Odense, Denmark, 4Aarhus Univ., Dept. of Publ. Hlth., Aarhus, Denmark
        10:10 AM – 10:20 AM
        20
        GREATER QUALITY OF EXERCISE THERAPY INTERVENTIONS IN ARTHROSCOPIC SURGERY TRIALS FOR DEGENERATIVE KNEE DISEASE INCREASES THE PAIN RELIEF
        E. M. Roos1, J. B. Thorlund1, L. S. Lohmander1,2, C. B. Juhl1,3; 1Univ. of Southern Denmark, Odense M, Denmark, 2Lund Univ., Lund, Sweden, 3Copenhagen Univ. Hosp., Copenhagen, Denmark
        10:20 AM – 10:30 AM
        21
        PREDICTORS AND OUTCOMES OF CROSS-OVER TO SURGERY IN A RANDOMIZED TRIAL OF SURGERY VS. PHYSICAL THERAPY FOR MENISCAL TEAR AND OSTEOARTHRITIS.
        Tabled 1
        9:00 AM – 10:30 AM

        Ballroom 6 B
        Concurrent Session 4:

        Cartilage Biology

        Moderator

        Amanda Fosang, PhD
        9:00 AM – 9:30 AMEndogenous Cellular and Molecular Mechanisms and Signalling Pathways of Cartilage Healing

        Frank Beier, PhD
        9:30 AM – 9:40 AM
        22
        THE ROLE OF ERYTHROMYCIN/GHRELIN AXIS IN ARTICULAR CARTILAGE MAINTENANCE
        L. Zeng1, T. Uchimura1, A. T. Foote1, T. Shi2, W. Ren2; 1Tufts Univ. Sch. of Med., Boston, MA, 2Wayne State Univ., Detroit, MI
        9:40 AM – 9:50 AM
        23
        DIO2-DEFICIENT MICE ARE PROTECTED AGAINST CARTILAGE DAMAGE IN A MODEL OF EXERCISE-INDUCED OA
        N. Bomer1,2, F. M. Cornelis3, Y. F. Ramos1, W. den Hollander1, L. Storms3, R. van der Breggen1, N. Lakenberg1, P. E. Slagboom1,2, I. Meulenbelt1, R. J. Lories3,4; 1LUMC, Leiden, Netherlands, 2Integrated research of Dev.al determinants of Ageing and Longevity (IDEAL), Leiden, Netherlands, 3Lab. of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Res. Ctr., KU Leuven, Leuven, Belgium, 4Div. of Rheumatology, Univ. Hosp. Leuven, Leuven, Belgium
        9:50 AM – 10:00 AM
        24
        SYNOVIAL MACROPHAGES PROMOTE TGF-β SIGNALING AFTER INTRA-ARTICULAR INJECTIONS OF OXIDIZED LDL IN NAÏVE MURINE KNEE JOINTS, PREVENTING PRODUCTION OF PRO-INFLAMMATORY FACTORS S100A8/9, CHEMOKINES AND AGGRECANASE-INDUCED NEO-EPITOPES
        W. de Munter1, A. B. Blom1, P. M. van der Kraan1, J. Roth2, T. Vogl2, W. B. van den Berg1, P. L. van Lent1; 1Radboud Univ. Med. Ctr., Nijmegen, Netherlands, 2Inst. of Immunology, Muenster, Germany
        10:00 AM – 10:10 AM
        25
        CONDITIONAL DELETION OF CTGF REVEALS A PIVOTAL ROLE FOR CTGF ON ACTIVATING THE LATENT COMPLEX OF TGFβ
        X. Tang, T. Vincent; Univ. of Oxford, Oxford, United Kingdom
        10:10 AM – 10:20 AM
        26
        PHLPP1 DELETION INCREASES FGF18 EXPRESSION AND PROTECTS AGAINST SURGICALLY-INDUCED OSTEOARTHRITIS
        E. W. Bradley1, L. R. Carpio1, D. F. Amanatullah1, S. Kakar1, L. E. Ta1, M. E. McGee-Lawrence2, A. C. Newton3, J. J. Westendorf1; 1Mayo Clinic, Rochester, MN, 2Georgia Regents Univ., Agusta, GA, 3Univ. of California, San Diego, CA
        10:20 AM – 10:30 AM
        27
        SYNOVIAL FLUID CONCENTRATION OF GREMLIN1 BUT NOT FRIZZLED-RELATED PROTEIN IS INCREASED IN PATIENTS AFTER ACUTE KNEE INJURY
        Tabled 1
        10:30 AM – 11:00 AMBREAK
        11:00 AM – 12:30 PM

        Ballroom 6 AB
        Plenary Session 3:

        Highest Rated Abstracts by Young Investigators

        Moderators:

        Katherine Boyer, PhD

        Jeffrey N.Katz, MD, MS
        11:00 AM – 11:10 AM
        28
        RECRUITMENT OF ENDOGENOUS CHONDROGENIC PROGENITOR CELLS FOR ARTICULAR CARTILAGE REPAIR
        Y. Yu, D. Seol, B. Marc, H. Zheng, J. Buckwalter, J. Martin; Univ. of Iowa, Iowa City, IA
        11:10 AM – 11:20 AM
        29
        AN AGGRECAN 32-MER FRAGMENT GENERATED IN OSTEOARTHRITIS DIRECTLY EXCITES NOCICEPTIVE NEURONS
        R. E. Miller1, R. J. Miller2, A. Belmadani2, S. B. Golub3, A. J. Fosang3, A-M. Malfait1; 1Rush Univ. Med. Ctr., Chicago, IL, 2Northwestern Univ., Chicago, IL, 3Univ. of Melbourne, Parkville, Australia
        11:20 AM – 11:30 AM
        30
        GREMLIN1 INDUCED BY EXCESSIVE MECHANICAL STRESS LOADING ENHANCES CARTILAGE DEGRADATION
        S. Chang1, H. Kobayashi1, K. Okada1, T. Okuma1, Y. Mori1, M. Kawata1, F. Yano2, H. Kawaguchi3, U-i. Chung4, S. Tanaka1, T. Saito2; 1Sensory and Motor System Med.,The Univ. Of Tokyo, Tokyo, Japan, 2Bone and Cartilage Regenerative Med., The Univ. Of Tokyo, Tokyo, Japan, 3Spine Ctr.,JCHO Tokyo Shinjuku Med. Ctr., Tokyo, Japan, 4Ctr. for Disease Biology and Integrative Med.,Faculty of Med.,The Univ. Of Tokyo, Tokyo, Japan
        11:30 AM – 11:40 AM
        31
        INCIDENCE, PREVALENCE, NATURAL COURSE AND PROGNOSIS OF PATELLOFEMORAL OSTEOARTHRITIS; DATA OF COHORT HIP AND COHORT KNEE STUDY
        N. E. Lankhorst1, J. Damen2, E. H. Oei2, J. A. Verhaar2, S. M. Bierma-Zeinstra1, M. van Middelkoop1; 1Erasmus MC, Univ. Med. Ctr., Rotterdam, Netherlands, 2Erasmus MC, Univ. Med. center, Rotterdam, Netherlands
        11:40 AM – 11:50 AM
        32
        ARE THE INFLAMMATORY MECHANISM DIFFERENTIALY REGULATED ACROSS DIFFERENT OSTEOARTHRITIC JOINTS
        G. Barreto1, M. Lalowski, Sr.2, R. Soliymani, Sr.2, E. Waris, Sr.3, Y. T. Konttinen, Sr.1,4; 1Inst. of Clinical Med.,Univ. of Helsinki, Helsinki, Finland, 2Meilahti Clinical Proteomics Core Facility,Univ. of Helsinki, Helsinki, Finland, 3Dept. of Hand Surgery, Univ. of Helsinki and Helsinki Univ. Central Hosp., Helsinki, Finland, 4ORTON Orthopaedic Inst. of the Invalid Fndn., Helsinki, Finland
        11:50 AM – 12:00 PM
        33
        PROGRANULIN PLAYS A CHONDROPROTECTIVE ROLE IN A SURGICALLY-INDUCED OSTEOARTHRITIS IN MICE THROUGH TNFR2 PATHWAY
        J. WEI, y. zhao, C. Liu; Orthopaedic Surgery of NYU, NYC, NY
        12:00 PM- 12:10 PM
        34
        WISP1
        AGGRAVATES OSTEOARTHRITIS BY MODULATION OF TGF-BETA SIGNALING AND POSITIVE REGULATION OF CANONICAL WNT SIGNALING
        M. H. van den Bosch1, A. B. Blom1, A. Maeda2, T. M. Kilts2, E. N. Blaney Davidson1, W. B. van den Berg1, F. P. Lafeber3, P. L. van Lent1, M. F. Young2, P. M. van der Kraan1; 1Radboud Univ. Med. center, Nijmegen, Netherlands, 2NIDCR/NIH, Bethesda, MD, 3Univ. Med. Ctr. Utrecht, Utrecht, Netherlands
        12:10 PM – 12:20 PM
        35
        THE ASSOCIATION OF OBESITY WITH INTERVERTEBRAL DISC DEGENERATION, DISC HERNIATION AND SPINAL STENOSIS: A MRI STUDY OF 1,684 PATIENTS
        Tabled 1
        12:20 PM – 12:30 PMQ & A
        12:30 PM – 2:00 PMLunch on Own
        2:00 PM – 3:30 PM

        Ballroom 6 A
        Concurrent Session 5:

        OA Therapy

        Moderators:

        Xavier Chevalier, MD

        Aileen Davis, PhD
        2:00 PM – 2:30 PMClinical Definitions of Early OA: Implications for Prevention

        George Peat, PhD, MCSP
        2:30 PM – 2:40 PM
        36
        EFFICACY OF A NOVEL, LOCALLY DELIVERED TRKA INHIBITOR IN PRECLINICAL MODELS OF OA AND JOINT PAIN
        C. R. Flannery, N. Moran, D. Blasioli, K. Donahue, J. Kane, T. Gladysheva, R. Dagher, R. Fang, A. Vardanyan, D. Bangari, C. Ho, A. Bourque, M. Santos, M. Philbrook, G. L. Matthews; Genzyme, Framingham, MA
        2:40 PM – 2:50 PM
        37
        EFFICACY OF HYDROXYCHLOROQUINE IN PRIMARY HAND OSTEOARTHRITIS: A RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED TRIAL
        W. C. Lee1, E. J. Ruijgrok1, A. E. Weel1, M. Kloppenburg2, M. R. Kok1, B. M. Boxma-de Klerk1, N. M. Basoski1; 1Maasstad Hosp., Rotterdam, Netherlands, 2Leiden Univ. Med. center, Leiden, Netherlands
        2:50 PM – 3:00 PM
        38
        THE EFFECT OF WALKING EXERCISE REGIMENS ON JOINT BIOMECHANICS AND SERUM BIOMARKER PROFILE IN PATIENTS WITH KNEE OSTEOARTHRITIS
        P. Jayabalan1, J. Gustafson2, S. Piva2, G. Sowa1, S. Farrokhi2; 1Dept. of Physical Med. & Rehabilitation, Univ. of Pittsburgh Med. Ctr., Pittsburgh, PA, 2Dept. of Physical Therapy, Univ. of Pittsburgh, Pittsburgh, PA
        3:00 PM – 3:10 PM
        39
        ADDRESSING CONTROVERSIES AROUND INTRA-ARTICULAR INJECTIONS WITH HYALURONIC ACID IN THE TREATMENT OF OSTEOARTHRITIS: META-REGRESSION ANALYSES OF RANDOMIZED TRIALS
        M. Johansen1,2, H. Bahrt1,2, R. Altman3, E. Bartels1, C. Juhl2,4, H. Bliddal1, H. Lund1,5, R. Christensen1; 1The Parker Inst., Dept. of Rheumatology. Bispebjerg and Frederiksberg Hosp., Copenhagen, Denmark, 2SEARCH, Inst. of Sports Sci. and Clinical Biomechanics, Faculty of Hlth.Sci., Univ. of Southern Denmark, Odense, Denmark, 3David Geffen Sch. of Med., Univ. of California, Los Angeles, CA, 4Dept. of Physiotherapy, Copenhagen Univ. Hosp., Gentofte, Hellerup, Denmark, 5Høgskolen i Bergen, Bergen, Norway
        3:10 PM – 3:20 PM
        40
        DOES PATELLO-FEMORAL BRACE THERAPY REDUCE SYNOVITIS ASSESSED BY DYNAMIC CONTRAST ENHANCED MRI?
        V. Swaminathan1, M. J. Parkes1, R. Hodgson1, M. J. Callaghan1, D. T. Felson2, T. W. O'Neill1; 1The Univ. of Manchester, Manchester, United Kingdom, 2Boston Univ., Boston, MA
        3:20 PM – 3:30 PM
        41
        PERCEIVED BARRIERS IN CARE FOR OSTEOARTHRITIS
        Tabled 1
        2:00 PM – 3:30 PM

        Ballroom 6 B
        Concurrent Session 6:

        Inflammation

        Moderators:

        Andreea Ioan, PhD

        Carla R. Scanzello, MD, PhD
        2:00 PM – 2:30 PMRegulation of Inflammation by Endogenous Danger Signals in Tissue Injury and Arthritis

        Anna M. Piccinini, PhD
        2:30 PM – 2:40 PM
        42
        FOLATE RECEPTOR POSITIVE MACROPHAGES IN OSTEOARTHRITIS AND EFFECTS OF TRIAMCINOLONE
        N. M. Korthagen1,2, M. Siebelt3, W. Wei3, H. C. Groen3, S. J. Koelewijn3, E. de Blois3, J. H. Waarsing3, M. de Jong3, G. J. van Osch3, Y. M. Bastiaansen-Jenniskens3, K. C. Santegoets2, J. A. van Roon2, K. Trumpi2, F. P. Lafeber2, P. R. van Weeren1, H. Weinans2; 1Utrecht Univ., Utrecht, Netherlands, 2Univ. Med. Ctr. Utrecht, Utrecht, Netherlands, 3Erasmus Med. Ctr., Rotterdam, Netherlands
        2:40 PM – 2:50 PM
        43
        S100 PROTEINS INDUCE CANONICAL WNT SIGNALING, WHICH CAUSES INCREASED EXPRESSION OF MMPS IN THE SYNOVIUM
        M. H. van den Bosch, A. B. Blom, P. Hoek, R. F. Schelbergen, W. B. van den Berg, P. M. van der Kraan, P. L. van Lent; Radboud Univ. Med. center, Nijmegen, Netherlands
        2:50 PM – 3:00 PM
        44
        ASSOCIATION BETWEEN TISSUE-INFLAMMATION BIOMARKERS AND PROGRESSION OF OSTEOARTHRITIS: EVIDENCE FROM THE ROTTERDAM STUDY
        F. Saberi Hosnijeh1, A. Siebuhr2, A. Uitterlinden1, A. Hofman1, M. Karsdal2, S. Bierma-Zeinstra1, A. Bay-Jensen2, J. van Meurs1; 1Erasmus Med. Ctr., Rotterdam, Netherlands, 2Nordic BioSci., Herlev, Denmark
        3:00 PM – 3:10 PM
        45
        INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR ALPHA IN SYNOVIAL FLUID ARE ASSOCIATED WITH PROGRESSION OF RADIOGRAPHIC OSTEOARTHRITIS IN SUBJECTS WITH PREVIOUS MENISCECTOMY
        S. Larsson1, M. Englund1,2, A. Struglics1, S. Lohmander1,3; 1Orthopaedics, Dept. of Clinical Sci. Lund, Lund Univ., Lund, Sweden, 2Clinical Epidemiology Res. & Training Unit, Boston Univ. Sch. of Med., Boston, MA, 3Res. Unit for Musculoskeletal Function and Physiotherapy and Dept. of Orthopaedics and Traumatology, Univ. of Southern Denmark, Odense, Denmark
        3:10 PM – 3:20 PM
        46
        ELEVATED PERIPHERAL BLOOD LEUKOCYTE INFLAMMATORY GENE EXPRESSION IN RADIOGRAPHIC PROGRESSORS WITH SYMPTOMATIC KNEE OSTEOARTHRITIS: NYU AND OAI COHORTS
        M. Attur1, A. Statnikov2, S. Krasnokutsky1, V. Kraus3, J. M. Jordan4, B. D. Mitchell5, M. Yau6, J. Patel1, C. F. Aliferis2, M. Hochberg6, J. Samuels1, S. B. Abramson1; 1NYU-Hosp. for Joint Diseases, New York, NY, 2Ctr. for Hlth.Informatics and Bioinformatics, NYU Langone Med. Ctr., New York, NY, 3Duke Univ. Sch. of Med., Durham, NC, 4Thurston Arthritis Res. Ctr., Univ. of North Carolina, Chapel Hill, NC, 5Dept.s of Med. and Epidemiology & Publ. Hlth., Univ. of Maryland Sch. of Med., Baltimore, MD, 6Dept.s of Med. and Epidemiology & Publ. Hlth., Univ. of Maryland Sch. of Med., Baltimore, Baltimore, MD
        3:20 PM – 3:30 PM
        47
        CHANGES IN ARGS-AGGRECAN, C-TERMINAL TYPE II AND N-TERMINAL TYPE I COLLAGEN TELOPEPTIDES, AND CYTOKINE CONCENTRATIONS OVER FIVE YEARS AFTER ANTERIOR CRUCIATE LIGAMENT INJURY
        Tabled 1
        3:30 PM – 5:00 PM

        Ballroom 6 CE
        POSTER SESSION 1

        Sponsored by Astellas
        5:00 PM – 6:30 PM

        Ballroom 6 A
        Concurrent Session 7:

        Clinical Aspects of OA

        Moderators:

        Nigel Arden, MD, MSc

        Lisa Mandl, MD, MPH
        5:00 PM – 5:30 PMThe Interactions of Osteoarthritis with Other Common Conditions

        Gillian Hawker MD, MSc
        5:30 PM – 5:40 PM
        48
        CARDIOMETABOLIC DISTURBANCES AND HAND OSTEOARTHRITIS: A CROSS-SECTIONAL AND LONGITUDINAL STUDY
        A. Courties1, J. Sellam1, E. Maheu1, C. Cadet2, Y. Barthe3, F. Carrat3, F. Berenbaum1; 1Rheumatology, Saint-Antoine Hosp., Inserm UMR S_938, UPMC Univ Paris 06, Assistance Publique–Hôpitaux de Paris (AP-HP), DHU i2B, Paris, France, 2Rheumatology, private office, Paris, France, 3Publ. Hlth., Saint-Antoine Hosp., Inserm UMRS_1136, UPMC Univ Paris 06, AP-HP, Paris, France
        5:40 PM – 5:50 PM
        49
        EFFECT OF SMOKING ON RADIOGRAPHIC KNEE OSTEOARTHRITIS AND CARTILAGE DAMAGE: THE MULTICENTER OSTEOARTHRITIS (MOST) STUDY
        J. Niu1, T. Neogi1, M. Nevitt2, A. Guermazi1, F. Roemer1, J. Torner3, C. E. Lewis4, D. Felson1; 1Boston Univ. Sch. of Med., Boston, MA, 2Univ. of Calfornia at San Francisco, San Francisco, CA, 3Univ. of Iowa at Iowa City, Iowa City, IA, 4Univ. of Alabama at Birmingham, Birmingham, AL
        5:50 PM – 6:00 PM
        50
        NOVEL METABOLIC MARKERS FOR CONCURRENCE OF OSTEOARTHRITIS AND DIABETES MELLITUS IDENTIFIED BY A METABOLOMICS APPROACH
        W. Zhang, L. Sergei, Y. Zhang, A-E. Erfan, P. Harper, E. Randell, R. Green, G. Martin, A. Furey, G. Sun, P. Rahman, G. Zhai; Mem. Univ. of Newfoundland, St. John's, NL, Canada
        6:00 PM – 6:10 PM
        51
        SERUM BONE METABOLIC MARKER AFFECTS THE LUMBAR OSTEOARTHRITIS IN A JAPANESE POPULATION STUDY
        D. Chiba1, K. Wada1, T. Tanaka1, G. Kumagai1, S. Chin1, E. Sasaki1, I. Takahashi2, S. Nakaji2, Y. Ishibashi1; 1Dept. of Orthopaedic Surgery, Hirosaki Univ. Graduate Sch. of Med., Hirosaki, Japan, 2Dept. of Social Med., Hirosaki Univ. Graduate Sch. of Med., Hirosaki, Japan
        6:10 PM – 6:20 PM
        52
        NATURAL HISTORY AND CLINICAL SIGNIFICANCE OF CARTILAGE DEFECTS OVER 10 YEARS IN A MID-LIFE COHORT
        H. Khan1, D. Aitken1, C. Ding1, L. Blizzard1, J-P. Pelletier2, J. Pelletier2, F. Cicuttini3, G. Jones1; 1Menzies Inst. of Med. Res., Univ. of Tasmania, Hobart, Tasmania, Australia, 2Osteoarthritis Res. Unit, Univ. of Montreal Hosp. Res. Ctr. (CRCHUM), Montreal, QC, Canada, 3Dept. of Epidemiology and Preventive Med., Monash Univ., Melbourne, Victoria, Australia
        6:20 PM – 6:30 PM
        53
        ADDITION OF CLINICAL MEASURES IMPROVES RISK-PREDICTION MODELS OF 30 DAY POST-TJR READMISSION
        Tabled 1
        5:00 PM – 6:30 PM

        Ballroom 6 B
        Concurrent Session 8:

        Joint Development

        Moderators:

        Frank Beier, PhD

        Rita Kandel, MD
        5:00 PM – 5:30 PMRegulation of Joint Development by Mechanical Factors

        Andy Pitsillides, PhD, BSc (Hons), FHEA
        5:30 PM – 5:40 PM
        54
        TWIST1 PROMOTES CATABOLIC RESPONSES AND ABNORMAL DIFFERENTIATION IN HUMAN CHONDROCYTES
        J. Hasei1, T. Teramura1, M. Olmer1, T. Ozaki2, H. Asahara1,3, M. K. Lotz1; 1The Scripps Res. Inst., La Jolla, CA, 2Okayama Univ., Okayama, Japan, 3NRICHD, Tokyo Med. and Dental Univ., Tokyo, Japan
        5:40 PM – 5:50 PM
        55
        ROLE OF BMP2 IN THE MATURATION AND MAINTENANCE OF THE KNEE JOINT
        L. Gamer1, K. Cox1, Q. Lin2, L. Han2, V. Rosen1; 1Harvard Sch. of Dental Med., Boston, MA, 2Drexel Univ., Philadelphia, PA
        5:50 PM – 6:00 PM
        56
        E11 PROTEIN STABILISATION BY PROTEASOME INHIBITION PROMOTES OSTEOCYTE DIFFERENTIATION AND MAY PROTECT AGAINST OSTEOARTHRITIS BONE PATHOLOGY
        K. A. Staines1, M. Prideaux2, P. Hohenstein1, D. J. Buttle3, A. A. Pitsillides4, C. Farquharson1; 1Roslin Inst., Univ. of Edinburgh, Edinburgh, Midlothian, United Kingdom, 2Univ. of Adelaide, Adelaide, Australia, 3Univ. of Sheffield, Sheffield, United Kingdom, 4Royal Vet. Coll., London, United Kingdom
        6:00 PM – 6:10 PM
        57
        PATHOGENESIS OF CAM MORPHOLOGY IN ENGLISH PREMIERSHIP FOOTBALLERS
        A. J. Palmer1, S. Folkard1, M. Gimpel2, J. Broomfield1, J. Newton1, E. McNally1, A. Taylor1, K. Javaid1, A. Carr1, S. Glyn-Jones1; 1Univ. of Oxford, Oxford, United Kingdom, 2Southampton Football Club, Southampton, United Kingdom
        6:10 PM – 6:20 PM
        58
        HIP SHAPE BY STATISTICAL SHAPE MODELING IS ASSOCIATED WITH LEG LENGTH INEQUALITY IN OLDER ADULTS
        Y. M. Golightly1, J. L. Stiller1, J. Cantrell1, J. B. Renner1, J. M. Jordan1, R. M. Aspden2, J. S. Gregory2, A. E. Nelson1; 1Univ. of North Carolina at Chapel Hill, Chapel Hill, NC, 2Univ. of Aberdeen, Aberdeen, United Kingdom
        6:20 PM – 6:30 PM
        59
        MECHANO-REGULATION OF WNT-SIGNALLING IN ARTICULAR CARTILAGE
        Tabled 1
        6:45 PM – 8:00 PM

        Room 606 – 609
        Meet the Professor Mentorship Session for Young Investigators Followed by Reception
        Saturday May 2, 2015
        7:30 AM – 8:30 AM

        Room 612
        Breakfast Workshop C

        Towards Better Animal Models of OA Pain with Higher Translational Value

        Jason McDougall. BSc, PhD
        7:30 AM – 8:30 AM

        Room 613-614
        Breakfast Workshop D

        OA Trial Bank

        Sita Bierma-Zeinstra, PhD
        9:00 AM – 10:30 AM

        Ballroom 6 A
        Concurrent Session 9:

        Pain Mechanism in OA

        Moderators:

        Tuhina Neogi, MD, PhD, FRCPC

        Tim McAlindon, MD, MPH
        9:00 AM – 9:30 AMNeurovascular Changes in the OA Joint

        David Walsh, PhD, FRCP
        9:30 AM – 9:40 AM
        60
        KNEE PAIN IS NOT RELATED TO ALTERATIONS IN THE MORPHOLOGY OR MRI SIGNAL OF THE INFRA-PATELLAR FAT PAD (IPFP) – A WITHIN-PERSON AND BETWEEN-PERSON ANALYSIS USING DATA FROM THE OSTEOARTHRITIS INITIATIVE (OAI)
        E. Steidle-Kloc, J. Dörrenberg, W. Wirth, A. Ruhdorfer, F. Eckstein; Inst. of Anatomy, Paracelsus Med. Univ., Salzburg, Austria
        9:40 AM – 9:50 AM
        61
        FUNCTIONAL MAGNETIC RESONANCE IMAGING EVALUATION OF PAIN CENTRAL SENSITIZATION PHENOMENA IN SUBJECTS WITH KNEE OSTEOARTHRITIS
        J. Monfort1,2, J. Pujol3, M. López-Ruiz3, J. Llorente-Onaindia1,2, G. Martínez-Vilavella3, D. Macià3, F. Montañes1, P. Benito1,2, J. Deus4; 1Rheumatology Dept.. Hosp. del Mar, Barcelona, Spain, 2Cell research group on inflamation and cartilage, Inst. Mar d'Investigacions Mèdiques, Barcelona, Spain, 3MRI Res. Unit. Hosp. del Mar, Barcelona, Spain, 4Dept. of Clinical and Hlth.Psychology, Autonomous Univ. of Barcelona, Barcelona, Spain
        9:50 AM – 10:00 AM
        62
        MOVEMENT CHARACTERISTICS ASSOCIATED WITH THE DEVELOPMENT OF CHRONIC KNEE PAIN
        M. C. Boling1, A. Nguyen2, R. Yau3, K. L. Cameron4, A. Beutler5, D. A. Padua3, S. Marshall3; 1Univ. of North Florida, Jacksonville, FL, 2High Point Univ., High Point, NC, 3Univ. of North Carolina, Chapel Hill, NC, 4Keller Army Hosp., West Point, NY, 5Uniformed Services Univ. of the Hlth.Sci., Bethesda, MD
        10:00 AM – 10:10 AM
        63
        IN VIVO CALCIUM IMAGING OF KNEE-INNERVATING DORSAL ROOT GANGLION NEURONS REVEALS INCREASED NEURONAL RESPONSIVENESS TO PHYSICAL STIMULI AFTER DMM SURGERY
        R. E. Miller1, K. Park2, S. Ishihara1, Y. Kim2, R. J. Miller3, X. Dong2, A-M. Malfait1; 1Rush Univ. Med. Ctr., Chicago, IL, 2Johns Hopkins Univ., Baltimore, MD, 3Northwestern Univ., Chicago, IL
        10:10 AM – 10:20 AM
        64
        RELATION OF SMOKING TO WIDESPREAD PAIN, KNEE PAIN SEVERITY, AND PAIN SENSITIZATION: THE MULTICENTER OSTEOARTHRITIS (MOST) STUDY
        J. Niu1, D. Felson1, L. Frey-Law2, M. Nevitt3, C. E. Lewis4, T. Neogi1; 1Boston Univ. Sch. of Med., Boston, MA, 2Univ. of Iowa at Iowa City, Iowa City, IA, 3Univ. of Calfornia at San Francisco, San Francisco, CA, 4Univ. of Alabama at Birmingham, Birmingham, AL
        10:20 AM – 10:30 AM
        65
        TGF-β IS A POTENT INDUCER OF NERVE GROWTH FACTOR IN ARTICULAR CARTILAGE VIA THE ALK5-SMAD2/3 PATHWAY. POTENTIAL ROLE IN OA RELATED PAIN?
        Tabled 1
        9:00 AM – 10:30 AM

        Ballroom 6 B
        Concurrent Session 10:

        Cell Signaling

        Moderators:

        Francesco Dell'Accio, MD, PhD

        Hiroshi Kawaguchi, MD, PhD
        9:00 AM – 9:30 AMRole of Zn2+ Import and the Zn2+/ZIP8/MTF1 Axis on OA

        Jang-Soo Chun, PhD
        9:30 AM – 9:40 AM
        66
        CITED2 MEDIATES CROSS-TALK BETWEEN MECHANICAL LOADING AND IL-4 AND RESULTS IN SYNERGISTIC CHONDROPROTECTION IN VITRO AND IN VIVO
        Z. He1, D. J. Leong1, L. Xu1, J. A. Hardin1, R. J. Majeska2, M. B. Schaffler2, M. M. Thi1, L. Cardoso2, M. B. Goldring3, N. J. Cobelli1, H. B. Sun1; 1Albert Einstein Coll. of Med., Bronx, NY, 2The City Coll. of New York, New York, NY, 3Hosp. for Special Surgery, New York, NY
        9:40 AM – 9:50 AM
        67
        JNK2 KNOCKOUT MICE ARE SIGNIFICANTLY PROTECTED FROM SURGICALLY INDUCED OSTEOARTHRITIS
        H. M. Ismail, J. Zarebska, T. Vincent, J. Saklatvala; Kennedy Inst. of Rheumatology, Univ. of Oxford, Oxford, United Kingdom
        9:50 AM – 10:00 AM
        68
        MEMBRANE-TYPE 1 MATRIX METALLOPROTEINASE CONTROLS OSTEO- AND CHONDROGENESIS BY A PROTEOLYSIS-INDEPENDENT MECHANISM MEDIATED BY ITS CYTOPLASMIC TAIL
        Q. Yang1, M. Attur1, T. Kirsch2, Y. J. Lee2, S. Yakar3, Z. Liu3, S. B. Abramson1, P. Mignatti1,4; 1NYU Sch. of Med. Dept. of Med., New York, NY, 2NYU Sch. of Med. Dept. of Orthopedic Surgery, New York, NY, 3NYU Coll. of Dentistry Dept. of Basic Sci. and Craniofacial Biology, New York, NY, 4NYU Sch. of Med. Dept. of Cell Biology, New York, NY
        10:00 AM – 10:10 AM
        69
        A DUAL ROLE FOR NOTCH SIGNALING IN JOINT CARTILAGE MAINTENANCE AND OSTEOARTHRITIS
        Z. Liu1, J. Chen2, A. J. Mirando2, C. Wang1, M. J. Zuscik1, R. J. O'Keefe3, M. J. Hilton2; 1Univ. of Rochester Med. Ctr., Rochester, NY, 2Duke Univ. Sch. of Med., Durham, NC, 3Washington Univ. Sch. of Med., St. Louis, MO
        10:10 AM – 10:20 AM
        70
        CELL -TO-CELL COMMUNICATION VIA GAP JUNCTIONS BETWEEN CARTILAGE, SYNOVIAL MEMBRANE AND SUBCHONDRAL BONE: IMPLICATIONS FOR JOINT HOMEOSTASIS
        P. Carpintero-Fernández1,2, P. Fernández-Puente3,2, R. Gago-Fuentes4, P. R. Brink5, F. J. Blanco6,7, M. D. Mayan1,2; 1Cartilage Biology Res. Group, Rheumatology Div., INIBIC, Hosp. Univ.rio A Coruña www.mayan-lab.com, A Coruña, Spain, 2Univ. of A Coruña (UDC), A Coruña, Spain, 3Rheumatology Div., ProteoRed/ISCIII, Proteomics Group, INIBIC, Hosp. Univ.rio A Coruña, A Coruña, Spain, 4Cartilage Biology Res. Group, Rheumatology Div., INIBIC, Hosp. Univ.rio A Coruña, A Coruña, Spain, 5Dept. of Physiology and Biophysics, State Univ. of New York, Stony Brook, New York, USA, New York, NY, 6Rheumatology Div., CIBER-BBN/ISCIII, INIBIC, Hosp. Univ.rio A Coruña, Xubias de Arriba 84, 15006 A Coruña, Spain, A Coruña, Spain, 7Rheumatology Div., ProteoRed/ISCIII, Proteomics Group, INIBIC, Hosp. Univ.rio A Coruña, Xubias de Arriba 84, 15006 A Coruña, Spain, A Coruña, Spain
        10:20 AM – 10:30 AM
        71
        CYSTEINE-MEDIATED REDOX REGULATION OF CELL SIGNALING IN CHONDROCYTES STIMULATED WITH FIBRONECTIN FRAGMENTS
        Tabled 1
        10:30 AM – 11:00 AMBREAK
        11:00 AM – 12:30 PM

        Ballroom 6 AB
        Plenary Session 4:

        Joint Homeostasis

        Moderators:

        Christopher Little, BVMS, PhD

        Martin Lotz, MD
        11:00 AM – 11:30 AMThe Circadian Clock in Cartilage Homeostasis

        Qing-Jun Meng, MD, PhD
        11:30 AM – 12:00 PMHow can Disturbances of the Nervous Systems Translate in OA Phenotypes?

        Francis Berenbaum, MD, PhD
        12:00 AM – 12:10 PM
        72
        QUANTITATIVE PROTEOMICS ANALYSIS OF CARTILAGE RESPONSE TO MECHANICAL INJURY AND CYTOKINE TREATMENT
        Y. Wang1, Y. Li1, A. Khabut2, S. Chubinskaya3, E. Ahrman2, A. J. Grodzinsky1, P. Onnerfjord2; 1MIT, Cambridge, MA, 2Dept. of Clinical Sci., Lund Univ., Lund, Sweden, 3Rush Univ. Med. Ctr., Chicago, IL
        12:10 AM – 12:20 PM
        73
        DYSREGULATED CIRCADIAN RHYTHM PATHWAY IN HUMAN OSTEOARTHRITIS: NR1D1 AND BMAL1 SUPPRESSION ALTERS TGF-Β AND IL-1Β SIGNALING IN CHONDROCYTES
        R. Akagi1, K. M. Fisch1, O. Alvarez-Garcia1, T. Teramura1, Y. Muramatsu1, M. Saito2, T. Sasho3, A. I. Su1, M. K. Lotz1; 1The Scripps Res. Inst., La Jolla, CA, 2Toho Univ. Sakura Med. Ctr., Sakura, Japan, 3Chiba Univ., Chiba, Japan
        12:20 AM – 12:30 PM
        74
        DIO2-KNOCKOUT MODULATES CIRCADIAN CLOCK GENES IN ARTICULAR CARTILAGE THROUGH THYROID HORMONE SIGNALING
        Tabled 1
        12:30 PM – 2:00 PMSatellite Symposia Sponsored by Bioiberica Room 606–609
        12:30 PM – 2:00 PMLunch on Own
        12:30 PM – 2:00 PM

        Room 613-614
        Young Investigator Workshop: How to Build Up a Research

        Group

        Martin Englund, MD, PhD

        Farshid Guilak, PhD

        Linda Sandell, PhD
        No additional fees required for this session. Limited to those age 40 and under. Must designate your attendance on the registration form. Lunch will be provided. Space is limited, register early
        2:00 PM – 3:30 PM

        Room 6 A
        Concurrent Session 11:

        Clinical Phenotypes

        Moderators:

        Rik Lories, MD, PhD

        Tim McAlindon, MD, MPH
        2:00 PM – 2:30 PM“Bony” Phenotype: Worthwhile as Therapeutic Target?

        JH Tobias, MD, PhD
        2:30 PM – 2:40 PM
        75
        INCIDENT BISPHOSPHONATE USE AND RISK OF KNEE REPLACEMENT SURGERY AMONG WOMEN WITH INCIDENT KNEE OSTEOARTHRITIS
        T. Neogi, C. Peloquin, Y. Zhang, D. Misra; Boston Univ. Sch. of Med., Boston, MA
        2:40 PM – 2:50 PM
        76
        THE ATROPHIC PHENOTYPE OF KNEE OSTEOARTHRITIS (OA) IS NOT ASSOCIATED WITH MORE RAPID PROGRESSION OF DISEASE WHEN COMPARED WITH THE NON-ATROPHIC PHENOTYPE: THE MOST STUDY.
        M. D. Crema1, D. T. Felson1, A. Guermazi1, M. C. Nevitt2, E. K. Quinn1, J. Niu1, J. A. Lynch2, M. D. Marra1, J. Torner3, C. E. Lewis4, F. W. Roemer1; 1Boston Univ., Boston, MA, 2Univ. of California at San Francisco, San Francisco, CA, 3Univ. of Iowa, Iowa City, IA, 4Univ. of Alabama, Birmingham, AL
        2:50 PM – 3:00 PM
        77
        CROSS-SECTINAL AND LONGITUDINAL ASSOCIATIONS BETWEEN SERUM LEVELS OF HIGH SENSITIVITY C-REACTIVE PROTEIN, RESISTIN AND KNEE BONE MARROW LESIONS IN PATIENTS WITH KNEE OSTEOARTHRITIS
        Z. Zhu1, X. Jing1, B. Wang2, A. Wluka2, B. Antony1, L. Laslett1, T. Winzenberg1, F. Cicuttini2, G. Jones1, C. Ding1; 1Menzies Inst. for Med. Res., Hobart, Australia, 2Dept. of Epidemiology and Preventive Med., Monash Univ., Melbourne, Melbourne, Australia
        3:00 PM – 3:10 PM
        78
        IDENTIFICATION OF AN INFLAMMATORY PHENOTYPE WITH HIGHER LIKELIHOOD OF PROGRESSION IN OA: ANALYSIS OF WOMAC PAIN SUB-QUESTIONS, C3M AND U-CTX-II FROM TWO PHASE 3 RANDOMIZED CLINICAL TRIALS WITH TREATMENT OF SYMPTOMATIC KNEE OSTEOARTHRITIS
        A. C. Bay-Jensen1, I. Byrjalsen1, K. Musa1, A. Bihlet1, P. Alexandersen2, J. R. Andersen1, B. J. Riis1, C. Christiansen1, M. A. Karsdal1, CSMC021C2301/2 investigators; 1Nordic BioSci. A/S, Herlev, Denmark, 2CCBR A/S, Vejle, Denmark
        3:10 PM – 3:20 PM
        79
        IMPROVED PHENOTYPE DEFINITIONS OF OA IN GENETIC ASSOCIATION STUDIES HIGHLIGHT A STRUCTURAL ROLE FOR A COMMON VARIANT IN LRCH1.
        K. Panoutsopoulou*1, S. Thiagarajah*2, A. G. Day-Williams1,3, L. Southam1, arcOGEN Consortium, M. Doherty4, E. Zeggini1, J. Wilkinson2; 1Wellcome Trust Sanger Inst., Hinxton, United Kingdom, 2Univ. of Sheffield, Sheffield, United Kingdom, 3Biogen Idec, Cambridge, MA, 4Univ. of Nottingham, Nottingham, United Kingdom
        3:20 PM – 3:30 PM
        80
        JOINT RELATED NEUROPATHIC PAIN IS ASSOCIATED WITH LOSS OF JOINT SPECIFIC FUNCTION AND QUALITY OF LIFE WITHIN HIP AND KNEE OSTEOARTHRITIS PATIENTS
        Tabled 1
        2:00 PM – 3:30 PM

        Room 6 B
        Concurrent Session 12:

        Genetics

        Moderators:

        Joyce van Meurs, PhD
        2:00 PM – 2:30 PMGenetic Links Between Development and Osteoarthritis: Dio2 gene and Risk for Osteoarthritis

        Ingrid Meulenbelt, PhD
        2:30 PM – 2:40 PM
        81
        GENETIC VARIANTS IN THE SUPT3H-RUNX2 LOCUS CONFER SUSCEPTIBILITY FOR BONE AND CARTILAGE RELATED DISORDERS VIA LONG-RANGE REGULATION OF RUNX2
        C. G. Boer1, R. Narcisi1, Y. F. Ramos2, W. den Hollander2, N. Bomer2, M. C. Castano Betancourt1, A. G. Uitterlinden1, G. van Osch1, I. Meulenbelt2, J. J. van Meurs1; 1Erasmus Med. Ctr., Rotterdam, Netherlands, 2Leiden Univ. Med. Ctr., Leiden, Netherlands
        2:40 PM – 2:50 PM
        82
        METHYLATION OF CARTILAGE DNA IS A MEDIATOR OF GENETIC RISK AT SEVERAL OA SUSCEPTIBILITY LOCI
        M. D. Rushton, L. N. Reynard, D. A. Young, C. Shepherd, R. Darlay, H. J. Cordell, J. Loughlin; Newcastle Univ., Newcastle upon Tyne, United Kingdom
        2:50 PM – 3:00 PM
        83
        THE CARBOHYDRATE SULFOTRANSFERASE GENE CHST11 IS REGULATED BY DNA METHYLATION WHICH IMPACTS ON THE FUNCTIONAL EFFECT OF THE OA GENETIC SUSCEPTIBILITY RESIDING AT THIS LOCUS
        L. N. Reynard, J. Loughlin; Newcastle Univ., Newcastle upon Tyne, United Kingdom
        3:00 PM – 3:10 PM
        84
        DIFFERENTIAL DNA METHYLATION AND REDUCED EXPRESSION OF CRITICAL TRANSCRIPTION FACTORS IN HUMAN OA CARTILAGE
        O. Alvarez-Garcia, K. M. Fisch, R. Akagi, A. I. Su, M. K. Lotz; The Scripps Res. Inst., La Jolla, CA
        3:10 PM – 3:20 PM
        85
        INSIGHTS INTO OSTEOARTHRITIS PROGRESSION REVEALED BY ANALYSES OF BOTH KNEE TIBIOFEMORAL COMPARTMENTS
        C-H. Chou1, M. Lee2, I-W. Song3, L-S. Lu3, J-Y. Wu3, Y-T. Chen3, V. B. Kraus1, C-C. Wu4; 1Duke Univ., Durham, NC, 2RIKEN Ctr. for Genomic Med., Yokohama, Japan, 3Inst. of BioMed. Sci., Academia Sinica, Taipei, Taiwan, 4Tri-Service Gen. Hosp., Natl. Defense Med. Ctr., Taipei, Taiwan
        3:20 PM – 3:30 PM
        86
        RISK PREDICTION USING EPIGENETIC PROFILES IN BLOOD OF OSTEOARTHRITIS PATIENTS.
        Tabled 1
        3:30 PM – 5:00 PM

        Ballroom 6 CE
        POSTER SESSION 2

        Sponsored by Bioventus
        6:30 PM – 8:30 PM

        Room 612
        2015 OARSI Highlights in Chinese
        6:30 PM – 8:30 PM

        Room 613–614
        2015 OARSI Highlights in Japanese
        5:00 PM – 6:00 PM

        Ballroom 6 AB
        Plenary Session 5: DEBATE Should OA Research Focus on “Mice” or “Men”?

        Moderators:

        Gillian Hawker, MD, MSc

        Ali Mobasheri, BSc, ARCS, MSc, DPhil(Oxon.)
        Chris Little, PhD – MICE

        vs.

        David Hunter, MBBS, PhD, FRACP – MEN
        8:00 PM – 12:00 AMCONGRESS DINNER
        Sunday May 3, 2015
        7:30 AM – 8:30 AM

        Room 612
        Breakfast Workshop E

        Osteoarthritis: Insights into Disease Initiation and Progression from MR Imaging

        Garry Gold, MD
        7:30 AM – 8:30 AM

        Room 613-614
        Breakfast Workshop F

        Value Of Future Epidemiologic Research In OA: The Art And Science Of Selecting An Appropriate Study Design

        Elena Losina, PhD
        9:00 AM – 10:30 AM

        Ballroom 6 A
        Concurrent Session 13

        Imaging

        Moderators:

        Jeffrey Duryea, PhD

        Graeme Jones, MD
        9:00 AM – 9:30 AMCurrent Status of the Art in Compositional Imaging of Joint Tissues

        Thomas Link, MD, PhD
        9:30 AM – 9:40 AM
        87
        ULTRASOUND-DETECTED INFLAMMATION PREDICTS RADIOGRAPHIC PROGRESSION IN HAND OSTEOARTHRITIS AFTER FIVE YEARS.
        A. Mathiessen, H. B. Hammer, B. Slatkowsky-Christensen, T. K. Kvien, I. K. Haugen; Diakonhjemmet Hosp., Oslo, Norway
        9:40 AM – 9:50 AM
        88
        PRESENCE OF MRI MARKERS OF INFLAMMATION ESPECIALLY IN OVERWEIGHT PERSONS INCREASES RISK OF INCIDENT OA: THE POMA STUDY
        F. W. Roemer1,2, A. Guermazi1, M. Hannon3, T. Fujii3, R. M. Boudreau3, D. J. Hunter4, F. Eckstein5, C. K. Kwoh6; 1Boston Univ. Sch. of Med., Boston, MA, 2Univ. of Erlangen-Nuremberg, Erlangen, Germany, 3Univ. of Pittsburgh, Pittsburgh, PA, 4Univ. of Sydney, Sydney, Australia, 5Paracelsus Med. Univ., Salzburg, Austria, 6Univ. of Arizona, Tucson, AZ
        9:50 AM – 10:00 AM
        89
        KNEE FLEXION MOMENT AND IMPULSE DURING WALKING ARE ASSOCIATED WITH PATELLOFEMORAL JOINT ARTICULAR CARTILAGE T1RHO AND T2 RELAXATION TIME
        H-L. Teng, N. Calixto, T. M. Link, S. Majumdar, R. B. Souza; Univ. of California, San Francisco, San Francisco, CA
        10:00 AM – 10:10 AM
        90
        DIAGNOSTIC PERFORMANCE OF SEMI-QUANTITATIVE KNEE ULTRASONOGRAPHY – COMPARISON WITH MAGNETIC RESONANCE IMAGING OSTEOARTHRITIS KNEE SCORE (MOAKS): DATA FROM THE OULU OSTEOARTHRITIS STUDY
        J. Podlipská1, A. Guermazi2, E. Liukkonen3, E. Lammentausta3, J. Niinimäki3, M. T. Nieminen3, O. Tervonen3, J. M. Koski4, S. Saarakkala1,3; 1Dept. of Med. Technology, Univ. of Oulu, Oulu, Finland, 2Dept. of Radiology, Boston Univ. Sch. of Med., Boston, MA, 3Dept. of Diagnostic Radiology, Oulu Univ. Hosp. and Univ. of Oulu, Oulu, Finland, 4Dept. of Internal Med., Mikkeli Central Hosp., Mikkeli, Finland
        10:10 AM – 10:20 AM
        91
        SIGNIFICANCE OF CHANGING VS. STABLE PRE-RADIOGRAPHIC MRI LESIONS IN PERSONS AT HIGHER RISK FOR KNEE OSTEOARTHRITIS
        L. Sharma1, R. Jackson2, O. Almagor1, F. Roemer3, A. Guermazi4, M. Crema4, M. C. Nevitt5, M. Hochberg6, K. Kwoh7, C. B. Eaton8, J. Bathon9, J. S. Chmiel1; 1Northwestern Univ., Chicago, IL, 2Ohio State Univ., Columbus, OH, 3Klinikum Augsburg, Augsburg, Germany, 4Boston Univ., Boston, MA, 5Univ. of California, San Francisco, CA, 6Univ. of Maryland, Baltimore, MD, 7Univ. of Arizona, Tucson, AZ, 8Brown Univ., Pawtucket, RI, 9Columbia Univ., New York, NY
        10:20 AM – 10:30 AM
        92
        SYNCHROTRON-BASED 3-D FUNCTIONAL MICRO-CT IMAGING OF DYNAMIC STRONTIUM LABEL TO LOCALIZE PATHOLOGICAL BONE ADAPTATIONS IN POST-TRAUMATIC OSTEOARTHRITIS
        Tabled 1
        9:00 AM – 10:30 AM

        Ballroom 6 B
        Concurrent Session 14:

        Skeletogenesis

        Moderators:

        Gerjo van Osch, PhD

        Nicole Walsh, PhD
        9:00 AM – 9:30 AMSoxC Transcription Factors in Skeletogenesis and Cartilage Differentiation

        Veronique Lefebvre, PhD
        9:30 AM – 9:40 AM
        93
        ACTIVIN RECEPTOR-LIKE KINASE ALK5 AND ALK1 ARE BOTH REQUIRED FOR TGFβ-INITIATED CHONDROGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS
        L. M. de Kroon1,2, E. N. Blaney Davidson1, R. Narcisi2, H. M. van Beuningen1, G. J. van Osch2, P. M. van der Kraan1; 1Radboud Univ. Med. Ctr., Nijmegen, Netherlands, 2Erasmus Univ. Med. Ctr., Rotterdam, Netherlands
        9:40 AM – 9:50 AM
        94
        AGRIN: A NEW PLAYER IN JOINT BIOLOGY AND A POTENT GROWTH FACTOR FOR CARTILAGE REGENERATION
        S. E. Eldridge; WHRI, London, United Kingdom
        9:50 AM – 10:00 AM
        95
        OSX-CRE DIRECTED ABLATION OF SITE-1 PROTEASE IN MICE RESULTS IN KYPHOSIS AND SCOLIOSIS
        D. Patra, L. Sandell; Washington Univ. Sch. of Med., St. Louis, MO
        10:00 AM – 10:10 AM
        96
        SOX9 DIRECTLY REGULATES CTGF/CCN2 TRANSCRIPTION IN GROWTH PLATE CHONDROCYTES AND IN NUCLEUS PULPOSUS CELLS OF INTERVERTEBRAL DISC
        C. Oh1, H. Yasuda2, S. Henry2, Z. Zhang2, M. Xue1, B. de Crombrugghe2, D. Chen1; 1Rush Univ. Med. Ctr., Chicago, IL, 2The Univ. of Texas, M.D. Anderson Cancer Ctr., Houston, TX
        10:10 AM – 10:20 AM
        97
        BAPX1/NKX3.2; A NOVEL CHONDROCYTE HYPERTROPHY MOLECULAR SWITCH IN OSTEOARTHRITIS
        M. M. Caron1, P. J. Emans1, D. A. Surtel1, P. M. van der Kraan2, L. W. van Rhijn1, T. J. Welting1; 1Maastricht Univ. Med. Ctr., Maastricht, Netherlands, 2Radboud Univ. Med. Ctr., Nijmegen, Netherlands
        10:20 AM – 10:30 AM
        98
        ALLOGENEIC MESENCHYMAL STEM CELLS IMPROVE INDICES OF LUMBAR INTERVERTEBRAL DISC DEGENERATION WITHOUT SITE SPECIFICITY OF INJECTION IN AN OVINE MODEL
        Tabled 1
        10:30 AM – 11:00 AMBREAK
        11:00 AM – 12:45 PM

        Ballroom 6 AB
        Plenary Session 6: YEAR IN REVIEW

        Moderators:

        Margreet Kloppenburg, MD, PhD

        Michael Nevitt, PhD, MPH
        Osteoarthritis Biology

        Anne- Marie Malfait, MD, PhD
        Clinical

        Leena Sharma, MD
        Genetics/Genomics

        Unnur Styrkarsdottir, PhD
        Imaging

        Flavia Cicuttini, MBBS, PhD, FRACP
        Biomarkers

        Anne-Christine Bay-Jensen, MSc, PhD
        Rehabilitation and Outcomes

        Kim Bennell, PhD, PT
        Mechanics

        Alan Grodzinsky, ScD