| Reviews |
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Article Title |
Author(s) |
Type |
Pages |
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Identifying the human aggrecanase
14 July 2010
Summary: It is clear that A Disintegrin And Metalloproteinase with ThromboSpondin motif (ADAMTS)-5 is the major aggrecanase in mouse cartilage, however it is not at all clear which enzyme is the major...
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A.J. Fosang,
F.M. Rogerson
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Review article
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pages 1109-1116
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Efficacy of ultrasound therapy for the management of knee osteoarthritis: a systematic review with meta-analysis
15 July 2010
Summary: Objective: To assess the efficacy of ultrasound therapy (US) for decreasing pain and improving physical function, patient-perception of disease severity, and cartilage repair in people with k...
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A. Loyola-Sánchez,
J. Richardson,
N.J. MacIntyre
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Review article
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pages 1117-1126
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| Original Articles |
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Article Title |
Author(s) |
Type |
Pages |
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Vascular disease is associated with facet joint osteoarthritis
14 July 2010
Summary: Objective: Epidemiologic studies have demonstrated associations between vascular disease and spinal degeneration. We sought to examine whether vascular disease was associated with lumbar spin...
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P. Suri,
J.N. Katz,
J. Rainville,
L. Kalichman,
A. Guermazi,
D.J. Hunter
et al.
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Full-length article
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pages 1127-1132
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Changes of human menisci in osteoarthritic knee joints
14 July 2010
Summary: Objective: To investigate the changes of knee menisci in osteoarthritis (OA) in human. Methods: OA and control menisci were obtained from 42 end-stage OA knees with medial involvement and 28 ...
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Y. Katsuragawa,
K. Saitoh,
N. Tanaka,
M. Wake,
Y. Ikeda,
H. Furukawa,
S. Tohma,
M. Sawabe,
M. Ishiyama,
S. Yagishita,
R. Suzuki,
H. Mitomi,
N. Fukui
et al.
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Full-length article
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pages 1133-1143
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Evidence of association between GDF5 polymorphisms and congenital dislocation of the hip in a Caucasian population
14 July 2010
Summary: Objective: Congenital dislocation of the hip (CDH) is a multifactorial disease which involves genetic factors that are still unidentified. Recently, a functional polymorphism (rs143383) of th...
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K. Rouault,
V. Scotet,
S. Autret,
F. Gaucher,
F. Dubrana,
D. Tanguy,
C. Yaacoub El Rassi,
B. Fenoll,
C. Férec
et al.
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Full-length article
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pages 1144-1149
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Development of a novel clinical biomarker assay to detect and quantify aggrecanase-generated aggrecan fragments in human synovial fluid, serum and urine
14 July 2010
Summary: Objective: Proteolytic degradation of aggrecan in articular cartilage is a hallmark feature of osteoarthritis (OA). The present study was aimed at developing a sensitive enzyme linked immunos...
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C.A. Swearingen,
J.W. Carpenter,
R. Siegel,
I.J. Brittain,
J. Dotzlaf,
T.B. Durham,
J.L. Toth,
D.A. Laska,
J. Marimuthu,
C. Liu,
D.P. Brown,
Q.L. Carter,
M.R. Wiley,
K.L. Duffin,
P.G. Mitchell,
K. Thirunavukkarasu
et al.
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Full-length article
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pages 1150-1158
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A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs
14 July 2010
Summary: Objective: To develop a short-term in vivo model in rats, with an enzyme-linked immunosorbent assay (ELISA) readout for specific aggrecanase-cleaved aggrecan fragments, to facilitate testing ...
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C.A. Swearingen,
M.G. Chambers,
C. Lin,
J. Marimuthu,
C.J. Rito,
Q.L. Carter,
J. Dotzlaf,
C. Liu,
S. Chandrasekhar,
K.L. Duffin,
P.G. Mitchell,
T.B. Durham,
M.R. Wiley,
K. Thirunavukkarasu
et al.
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Full-length article
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pages 1159-1166
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Hypoxia, RONS and energy metabolism in articular cartilage
14 July 2010
Summary: Objective: Increased pro-inflammatory cytokines and reactive oxygen and nitrogen species (RONS) occur in osteoarthritis (OA). Oxygen tension can alter the levels of RONS induced by interleuki...
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B. Fermor,
A. Gurumurthy,
B.O. Diekman
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Full-length article
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pages 1167-1173
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Surface grafting of biocompatible phospholipid polymer MPC provides wear resistance of tibial polyethylene insert in artificial knee joints
14 July 2010
Summary: Objective: Aseptic loosening of artificial knee joints induced by wear particles from a tibial polyethylene (PE) insert is a serious problem limiting their longevity. This study investigated ...
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T. Moro,
Y. Takatori,
M. Kyomoto,
K. Ishihara,
K. Saiga,
K. Nakamura,
H. Kawaguchi
et al.
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Full-length article
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pages 1174-1182
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Pretreatment of periosteum with TGF-β1 in situ enhances the quality of osteochondral tissue regenerated from transplanted periosteal grafts in adult rabbits
14 July 2010
Summary: Objective: To compare the efficacy of in situ transforming growth factor-beta1 (TGF-β1)-pretreated periosteum to untreated periosteum for regeneration of osteochondral tissue in rabbits. Meth...
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A. Olivos-Meza,
J.S. Fitzsimmons,
M.E. Casper,
Q. Chen,
K.-N. An,
T.J. Ruesink,
S.W. O’Driscoll,
G.G. Reinholz
et al.
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Full-length article
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pages 1183-1191
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Glucosamine sulfate reduces experimental osteoarthritis and nociception in rats: association with changes of mitogen-activated protein kinase in chondrocytes
31 May 2010
Summary: Objective: To study the effects of oral glucosamine sulfate on the development of osteoarthritis (OA) and to examine concomitant changes in the nociceptive behavior of rats. Methods: OA was i...
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Z.-H. Wen,
C.-C. Tang,
Y.-C. Chang,
S.-Y. Huang,
S.-P. Hsieh,
C.-H. Lee,
G.-S. Huang,
H.-F. Ng,
C.-A. Neoh,
C.-S. Hsieh,
W.-F. Chen,
Y.-H. Jean
et al.
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Full-length article
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pages 1192-1202
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p38γ mitogen-activated protein kinase suppresses chondrocyte production of MMP-13 in response to catabolic stimulation
14 July 2010
Summary: Objective: The signaling protein p38 mitogen-activated protein kinase is required for inflammatory signaling in chondrocytes that regulates matrix metalloproteinase (MMP) production. We sough...
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D.L. Long,
R.F. Loeser
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Full-length article
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pages 1203-1210
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Detection of degenerative cartilage disease: comparison of high-resolution morphological MR and quantitative T2 mapping at 3.0 Tesla
14 July 2010
Summary: Objective: The aim of the study was to investigate the association of T2 relaxation times of the knee with early degenerative cartilage changes. Furthermore the impact of unloading the knee o...
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S. Apprich,
G.H. Welsch,
T.C. Mamisch,
P. Szomolanyi,
M. Mayerhoefer,
K. Pinker,
S. Trattnig
et al.
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Full-length article
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pages 1211-1217
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Mitochondrial function is altered in articular chondrocytes of an endemic osteoarthritis, Kashin–Beck disease
21 July 2010
Summary: Objective: Kashin–Beck disease (KBD) is an endemic degenerative osteoarthritis (OA) associated with extracellular matrix degradation and chondrocyte necrosis in the articular and growth plate...
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J.T. Liu,
X. Guo,
W.J. Ma,
Y.G. Zhang,
P. Xu,
J.F. Yao,
Y.D. Bai
et al.
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Full-length article
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pages 1218-1226
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Association of radiographic and symptomatic knee osteoarthritis with health-related quality of life in a population-based cohort study in Japan: the ROAD study
14 July 2010
Summary: Objective: Knee osteoarthritis (OA) is a major public health issue causing chronic pain and disability. However, there is little information on the impact of this disease on quality of life (...
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S. Muraki,
T. Akune,
H. Oka,
Y. En-yo,
M. Yoshida,
A. Saika,
T. Suzuki,
H. Yoshida,
H. Ishibashi,
F. Tokimura,
S. Yamamoto,
K. Nakamura,
H. Kawaguchi,
N. Yoshimura
et al.
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Full-length article
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pages 1227-1234
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| Letters to the Editor |
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Article Title |
Author(s) |
Type |
Pages |
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OARSI update on the evidence for osteoarthritis therapies: comment on the nomenclature used for intra-articular hyaluronan
14 July 2010
Please allow me to clarify the terminology used to describe the intra-articular hyaluronan (IAHA) class of osteoarthritis (OA) treatments, in the excellent evidence update reported by Zhang et al. (OA...
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P.A. Band
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Correspondence
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page 1235
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Response from authors: ‘OARSI update on the evidence for osteoarthritis therapies’
14 July 2010
We appreciate Dr Philip Band’s letter in response to our recent publication OARSI recommendations for the management of hip and knee osteoarthritis Part III: changes in evidence following systematic c...
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W. Zhang,
G. Nuki
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Correspondence
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page 1236
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