Osteoarthritis and Cartilage
Volume 18, Issue 11 , Pages 1477-1486 , November 2010

Adult bone marrow stromal cell-based tissue-engineered aggrecan exhibits ultrastructure and nanomechanical properties superior to native cartilage

  • H.-Y. Lee

      Affiliations

    • Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States
    • ,
  • P.W. Kopesky

      Affiliations

    • Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States
    • ,
  • A. Plaas

      Affiliations

    • Department of Biochemistry, Rush University Medical Center, Chicago, IL, United States
    • ,
  • J. Sandy

      Affiliations

    • Department of Biochemistry, Rush University Medical Center, Chicago, IL, United States
    • ,
  • J. Kisiday

      Affiliations

    • Equine Orthopaedic Research Center, Colorado State University, Fort Collins, CO, United States
    • ,
  • D. Frisbie

      Affiliations

    • Equine Orthopaedic Research Center, Colorado State University, Fort Collins, CO, United States
    • ,
  • A.J. Grodzinsky

      Affiliations

    • Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States
    • Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States
    • Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States
    • ,
  • C. Ortiz

      Affiliations

    • Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States
    • Corresponding Author InformationAddress correspondence and reprint requests to: C. Ortiz, Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States. Tel: 1-617-452-3084.

Received 21 January 2010 ,Accepted 30 July 2010.

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PII: S1063-4584(10)00253-0

doi: 10.1016/j.joca.2010.07.015

Osteoarthritis and Cartilage
Volume 18, Issue 11 , Pages 1477-1486 , November 2010

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