Osteoarthritis and Cartilage
Volume 18, Issue 10 , Pages 1355-1357 , October 2010

Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis

  • J.J. McDougall

      Affiliations

    • Department of Physiology & Pharmacology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada
    • Corresponding Author InformationAddress correspondence and reprint requests to: Jason J. McDougall, Department of Physiology & Pharmacology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada. Tel: 1-403-2204507; Fax:1-403-2103949.
    • ,
  • N. Schuelert

      Affiliations

    • Department of Physiology & Pharmacology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada
    • ,
  • J. Bowyer

      Affiliations

    • Respiratory & Inflammation Research Area, AstraZeneca, Charnwood, Loughborough, Leicestershire LE11 5RH, UK

Received 18 May 2010 ,Accepted 30 July 2010.

References 

  1. Bendele AM, Hulman JF. Spontaneous cartilage degeneration in guinea pigs. Arthritis Rheum. 1988;31:561–565
  2. McDougall JJ, Andruski B, Schuelert N, Hallgrimsson B, Matyas JR. Unravelling the relationship between age, nociception and joint destruction in naturally occurring osteoarthritis of Dunkin Hartley guinea pigs. Pain. 2009;141:222–232
  3. McDougall JJ, Hanesch U, Pawlak M, Schmidt RF. Participation of NK1 receptors in nociceptin-induced modulation of rat knee joint mechanosensitivity. Exp Brain Res. 2001;137:249–253
  4. Morko J, Kiviranta R, Mulari MT, Ivaska KK, Vaananen HK, Vuorio E, et al. Overexpression of cathepsin K accelerates the resorption cycle and osteoblast differentiation in vitro. Bone. 2009;44:717–728
  5. Morko JP, Soderstrom M, Saamanen AM, Salminen HJ, Vuorio EI. Up regulation of cathepsin K expression in articular chondrocytes in a transgenic mouse model for osteoarthritis. Ann Rheum Dis. 2004;63:649–655
  6. Garnero P, Piperno M, Gineyts E, Christgau S, Delmas PD, Vignon E. Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage. Ann Rheum Dis. 2001;60:619–626
  7. McDougall JJ. Arthritis and Pain. Neurogenic origin of joint pain. Arthritis Res Ther. 2006;8:220–229
  8. Niv D, Gofeld M, Devor M. Causes of pain in degenerative bone and joint disease: a lesson from vertebroplasty. Pain. 2003;105:387–392
  9. Bove SE, Calcaterra SL, Brooker RM, Huber CM, Guzman RE, Juneau PL, et al. Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. Osteoarthritis Cartilage. 2003;11:821–830
  10. Bove SE, Laemont KD, Brooker RM, Osborn MN, Sanchez BM, Guzman RE, et al. Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia. Osteoarthritis Cartilage. 2006;14:1041–1048
  11. McDougall JJ, Watkins L, Li Z. Vasoactive intestinal peptide (VIP) is a modulator of joint pain in a rat model of osteoarthritis. Pain. 2006;123:98–105
  12. McDougall JJ. Pain and OA. J Musculoskelet Neuronal Interact. 2006;6:385–386
  13. Brandt KD, Mazzuca SA, Katz BP, Lane KA, Buckwalter KA, Yocum DE, et al. Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum. 2005;52:2015–2025
  14. Bowyer J, Heapy CG, Flannelly JK, Waterton JC, Maciewicz RA. Evaluation of a magnetic resonance biomarker of osteoarthritis disease progression: doxycycline slows tibial cartilage loss in the Dunkin Hartley guinea pig. Int J Exp Pathol. 2009;90:174–181

PII: S1063-4584(10)00252-9

doi: 10.1016/j.joca.2010.07.014

Osteoarthritis and Cartilage
Volume 18, Issue 10 , Pages 1355-1357 , October 2010

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