Osteoarthritis and Cartilage
Volume 18, Issue 9 , Pages 1159-1166 , September 2010

A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs

  • C.A. Swearingen

      Affiliations

    • Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • These authors contributed equally to this work.
    • ,
  • M.G. Chambers

      Affiliations

    • Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • These authors contributed equally to this work.
    • ,
  • C. Lin

      Affiliations

    • Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • J. Marimuthu

      Affiliations

    • Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • C.J. Rito

      Affiliations

    • Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • Q.L. Carter

      Affiliations

    • Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • J. Dotzlaf

      Affiliations

    • Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • C. Liu

      Affiliations

    • Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • S. Chandrasekhar

      Affiliations

    • Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • K.L. Duffin

      Affiliations

    • Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • P.G. Mitchell

      Affiliations

    • Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • T.B. Durham

      Affiliations

    • Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • M.R. Wiley

      Affiliations

    • Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • K. Thirunavukkarasu

      Affiliations

    • Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • Corresponding Author InformationAddress correspondence and reprint requests to: Kannan Thirunavukkarasu, Drop Code 0403, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285.

Received 12 October 2009 ,Accepted 6 February 2010.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.

PII: S1063-4584(10)00215-3

doi: 10.1016/j.joca.2010.02.019

Osteoarthritis and Cartilage
Volume 18, Issue 9 , Pages 1159-1166 , September 2010

Article Tools

* Image Usage & Resolution