A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs

Swearingen, C.A.; Chambers, M.G.; Lin, C.; Marimuthu, J.; Rito, C.J.; Carter, Q.L.; Dotzlaf, J.; Liu, C.; Chandrasekhar, S.; Duffin, K.L.; Mitchell, P.G.; Durham, T.B.; Wiley, M.R.; Thirunavukkarasu, K.

doi:10.1016/j.joca.2010.02.019

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Volume 18, Issue 9 , Pages 1159-1166, September 2010

A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs

C.A. Swearingen
- Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
- These authors contributed equally to this work.
M.G. Chambers
- Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
- These authors contributed equally to this work.
C. Lin
- Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
J. Marimuthu
- Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
C.J. Rito
- Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
Q.L. Carter
- Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
J. Dotzlaf
- Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
C. Liu
- Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
S. Chandrasekhar
- Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
K.L. Duffin
- Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
P.G. Mitchell
- Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
T.B. Durham
- Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
M.R. Wiley
- Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
K. Thirunavukkarasu
- Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
- Address correspondence and reprint requests to: Kannan Thirunavukkarasu, Drop Code 0403, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285.