Osteoarthritis and Cartilage
Volume 18, Issue 9 , Pages 1150-1158 , September 2010

Development of a novel clinical biomarker assay to detect and quantify aggrecanase-generated aggrecan fragments in human synovial fluid, serum and urine

  • C.A. Swearingen

      Affiliations

    • Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • These authors contributed equally to this work.
    • ,
  • J.W. Carpenter

      Affiliations

    • Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • These authors contributed equally to this work.
    • ,
  • R. Siegel

      Affiliations

    • Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • I.J. Brittain

      Affiliations

    • Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • J. Dotzlaf

      Affiliations

    • Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • T.B. Durham

      Affiliations

    • Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • J.L. Toth

      Affiliations

    • Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • D.A. Laska

      Affiliations

    • Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • J. Marimuthu

      Affiliations

    • Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • C. Liu

      Affiliations

    • Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • D.P. Brown

      Affiliations

    • Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • Q.L. Carter

      Affiliations

    • Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • M.R. Wiley

      Affiliations

    • Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • K.L. Duffin

      Affiliations

    • Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • P.G. Mitchell

      Affiliations

    • Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • ,
  • K. Thirunavukkarasu

      Affiliations

    • Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    • Corresponding Author InformationAddress correspondence and reprint requests to: Kannan Thirunavukkarasu, Drop Code 0403, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285.

Received 7 November 2009 ,Accepted 10 June 2010.

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PII: S1063-4584(10)00214-1

doi: 10.1016/j.joca.2010.06.011

Osteoarthritis and Cartilage
Volume 18, Issue 9 , Pages 1150-1158 , September 2010

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