Development of a novel clinical biomarker assay to detect and quantify aggrecanase-generated aggrecan fragments in human synovial fluid, serum and urine

Swearingen, C.A.; Carpenter, J.W.; Siegel, R.; Brittain, I.J.; Dotzlaf, J.; Durham, T.B.; Toth, J.L.; Laska, D.A.; Marimuthu, J.; Liu, C.; Brown, D.P.; Carter, Q.L.; Wiley, M.R.; Duffin, K.L.; Mitchell, P.G.; Thirunavukkarasu, K.

doi:10.1016/j.joca.2010.06.011

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Volume 18, Issue 9 , Pages 1150-1158, September 2010

Development of a novel clinical biomarker assay to detect and quantify aggrecanase-generated aggrecan fragments in human synovial fluid, serum and urine

C.A. Swearingen
- Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
- These authors contributed equally to this work.
J.W. Carpenter
- Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
- These authors contributed equally to this work.
R. Siegel
- Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
I.J. Brittain
- Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
J. Dotzlaf
- Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
T.B. Durham
- Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
J.L. Toth
- Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
D.A. Laska
- Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
J. Marimuthu
- Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
C. Liu
- Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
D.P. Brown
- Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
Q.L. Carter
- Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
M.R. Wiley
- Discovery Chemistry, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
K.L. Duffin
- Integrative Biology, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
P.G. Mitchell
- Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
K. Thirunavukkarasu
- Musculoskeletal Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
- Address correspondence and reprint requests to: Kannan Thirunavukkarasu, Drop Code 0403, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285.