Osteoarthritis and Cartilage
Volume 18, Issue 3 , Pages 297-302 , March 2010

The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination

  • C.G. Jackson

      Affiliations

    • University of Utah School of Medicine, Salt Lake City, UT, USA
    • Drs Christopher Jackson and Anna Plaas contributed equally to this study.
  • ,
  • A.H. Plaas

      Affiliations

    • Rush University Medical Center, Chicago IL, USA
    • Drs Christopher Jackson and Anna Plaas contributed equally to this study.
  • ,
  • J.D. Sandy

      Affiliations

    • Rush University Medical Center, Chicago IL, USA
    • Corresponding Author InformationAddress correspondence and reprint requests to: John D. Sandy, Rush University Medical Center, Chicago, IL 60612, USA. Tel: 1-312-942-7810; Fax: 1-312-942-3053.
  • ,
  • C. Hua

      Affiliations

    • Department of Internal Medicine, College of Medicine, University of South Florida, Tampa, FL, USA
  • ,
  • S. Kim-Rolands

      Affiliations

    • Department of Internal Medicine, College of Medicine, University of South Florida, Tampa, FL, USA
  • ,
  • J.G. Barnhill

      Affiliations

    • Albuquerque VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM, USA
    • University of New Mexico College of Pharmacy, Albuquerque, NM, USA
  • ,
  • C.L. Harris

      Affiliations

    • Albuquerque VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM, USA
  • ,
  • D.O. Clegg

      Affiliations

    • University of Utah School of Medicine, Salt Lake City, UT, USA

Received 19 June 2009 ,Accepted 23 October 2009.

References 

  1. Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, et al. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum. 1998;41:778–799
  2. McNair PJ, Simmonds MA, Boocock MG, Larmer PJ. Exercise therapy for the management of osteoarthritis of the hip joint: a systematic review. Arthritis Res Ther. 2009;11:R98
  3. Reichmann WM, Katz JN, Kessler CL, Jordan JM, Losina E. Determinants of self-reported health status in a population-based sample of persons with radiographic knee osteoarthritis. Arthritis Rheum. 2009;61:1046–1053
  4. Corsinovi L, Martinelli E, Fonte G, Astengo M, Sona A, Gatti A, et al. Efficacy of oxycodone/acetaminophen and codeine/acetaminophen vs conventional therapy in elderly women with persistent, moderate to severe osteoarthritis-related pain. Arch Gerontol Geriatr. 2009;
  5. Hochberg MC. Nutritional supplements for knee osteoarthritis–still no resolution. N Engl J Med. 2006;354:858–860
  6. Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006;354:795–808
  7. Laverty S, Sandy JD, Celeste C, Vachon P, Marier JF, Plaas AH. Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant doses. Arthritis Rheum. 2005;52:181–191
  8. Plaas AH, West L, Midura RJ, Hascall VC. Disaccharide composition of hyaluronan and chondroitin/dermatan sulfate. Analysis with fluorophore-assisted carbohydrate electrophoresis. Methods Mol Biol. 2001;171:117–128
  9. Zhong S, Zhong D, Chen X. Improved and simplified liquid chromatography/electrospray ionization mass spectrometry method for the analysis of underivatized glucosamine in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;854:291–298
  10. Persiani S, Rotini R, Trisolino G, Rovati LC, Locatelli M, Paganini D, et al. Synovial and plasma glucosamine concentrations in osteoarthritic patients following oral crystalline glucosamine sulphate at therapeutic dose. Osteoarthritis Cartilage. 2007;15:764–772
  11. Meulyzer M, Vachon P, Beaudry F, Vinardell T, Richard H, Beauchamp G, et al. Comparison of pharmacokinetics of glucosamine and synovial fluid levels following administration of glucosamine sulphate or glucosamine hydrochloride. Osteoarthritis Cartilage. 2008;16:973–979
  12. Myers AL, Upreti VV, Khurana M, Eddington ND. Characterization of total plasma glycosaminoglycan levels in healthy volunteers following oral administration of a novel antithrombotic odiparcil with aspirin or enoxaparin. J Clin Pharmacol. 2008;48:1158–1170
  13. Zinellu A, Pisanu S, Zinellu E, Lepedda AJ, Cherchi GM, Sotgia S, et al. A novel LIF-CE method for the separation of hyaluronan- and chondroitin sulfate-derived disaccharides: application to structural and quantitative analyses of human plasma low- and high-charged chondroitin sulfate isomers. Electrophoresis. 2007;28:2439–2447
  14. Fox BA, Stephens MM. Glucosamine/chondroitin/primorine combination therapy for osteoarthritis. Drugs Today (Barc). 2009;45:21–31
  15. Vangsness CT, Spiker W, Erickson J. A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis. Arthroscopy. 2009;25:86–94
  16. Tat SK, Pelletier JP, Verges J, Lajeunesse D, Montell E, Fahmi H, et al. Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study. Arthritis Res Ther. 2007;9:R117
  17. Theodosakis J. A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee. J Rheumatol. 2004;31:826;author reply 826–827
  18. Volpi N. HPLC and on-line MS detection for the analysis of chondroitin sulfates/hyaluronan disaccharides derivatized with 2-aminoacridone. Anal Biochem. 2009;
  19. Matsuzaki H, Kobayashi H, Yagyu T, Wakahara K, Kondo T, Kurita N, et al. Plasma bikunin as a favorable prognostic factor in ovarian cancer. J Clin Oncol. 2005;23:1463–1472
  20. Zhuo L, Salustri A, Kimata K. A physiological function of serum proteoglycan bikunin: the chondroitin sulfate moiety plays a central role. Glycoconj J. 2002;19:241–247
  21. Boudry G, Cheeseman CI, Perdue MH. Psychological stress impairs Na+-dependent glucose absorption and increases GLUT2 expression in the rat jejunal brush-border membrane. Am J Physiol Regul Integr Comp Physiol. 2007;292:R862–867
  22. Petersen SG, Saxne T, Heinegard D, Hansen M, Holm L, Koskinen S, et al. Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training. Osteoarthritis Cartilage. 2010;18:34–40
  23. Block JA, Oegema TR, Sandy JD, Plaas A. The effects of oral glucosamine on joint health: is a change in research approach needed?. Osteoarthritis Cartilage. 2010;18:5–11

PII: S1063-4584(09)00290-8

doi: 10.1016/j.joca.2009.10.013

Osteoarthritis and Cartilage
Volume 18, Issue 3 , Pages 297-302 , March 2010