Osteoarthritis and Cartilage
Volume 18, Issue 1 , Pages 82-87 , January 2010

Elevated osteopontin level of synovial fluid and articular cartilage is associated with disease severity in knee osteoarthritis patients

  • S.G. Gao

      Affiliations

    • Department of Orthopaedics, Xiangya Hospital, Central South University, # 87 Xiangya Road, Changsha, Hunan 410008, China
    • These authors contributed equally to this paper.
  • ,
  • K.H. Li

      Affiliations

    • Department of Orthopaedics, Xiangya Hospital, Central South University, # 87 Xiangya Road, Changsha, Hunan 410008, China
    • These authors contributed equally to this paper.
  • ,
  • K.B. Zeng

      Affiliations

    • Department of Orthopaedics, Xiangya Hospital, Central South University, # 87 Xiangya Road, Changsha, Hunan 410008, China
    • Department of Spinal Surgery, Central Hospital of Xiangtan, # 120 Heping Road, Xiangtan, Hunan 411100, China
  • ,
  • M. Tu

      Affiliations

    • Department of Orthopaedics, Xiangya Hospital, Central South University, # 87 Xiangya Road, Changsha, Hunan 410008, China
    • Department of Orthopaedics, Second People Hospital of Jingmen, # 39 Xiangshan Road, Jingmen, Hubei 448000, China
  • ,
  • M. Xu

      Affiliations

    • Department of Orthopaedics, Xiangya Hospital, Central South University, # 87 Xiangya Road, Changsha, Hunan 410008, China
  • ,
  • G.H. Lei

      Affiliations

    • Department of Orthopaedics, Xiangya Hospital, Central South University, # 87 Xiangya Road, Changsha, Hunan 410008, China
    • Corresponding Author InformationAddress correspondence and reprint requests to: Guang-Hua Lei, Department of Orthopaedics, Xiangya Hospital, Central South University, No.87 Xiangya Road, Changsha, Hunan 410008, China. Tel: 86-731-84327389, 86-13808429640; Fax: 86-731-84327354.

Received 24 February 2009 ,Accepted 31 July 2009.

References 

  1. Sodek J, Ganss B, McKee MD. Osteopontin. Crit Rev Oral Biol Med. 2000;11:279–303
  2. Xie Y, Sakatsume M, Nishi S, Narita I, Arakawa M, Gejyo F. Expression, roles, receptors, and regulation of osteopontin in the kidney. Kidney Int. 2001;60:1645–1657
  3. Denhardt D, Noda M. Osteopontin expression and function: role in bone remodeling. J Cell Biochem Suppl. 1998;30-31:92–102
  4. Gravallese EM. Osteopontin: a bridge between bone and the immune system. J Clin Invest. 2003;112:147–149
  5. O'Regan AW, Nau GJ, Chupp GL, Berman JS. Osteopontin (Eta-1) in cell6 mediated immunity: teaching an old dog new tricks. Immunol Today. 2000;21:475–478
  6. McKee MD, Nanci A. Osteopontin at mineralized tissue interfaces in bone, teeth, and osseointegrated implants: ultrastructural distribution and implications for mineralized tissue formation, turnover, and repair. Microsc Res Tech. 1996;33(2):141–164
  7. Standal T, Borset M, Sundan A. Role of osteopontin in adhesion, migration, cell survival and bone remodeling. Exp Oncol. 2004;26(3):179–184
  8. Chellaiah MA, Hruska KA. The integrin alpha(v)beta(3) and CD44 regulate the actions of osteopontin on osteoclast motility. Calcif Tissue Int. 2003;72(3):197–205
  9. Suzuki K, Zhu B, Rittling SR, Denhardt DT, Goldberg HA, McCulloch CA, et al. Colocalization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts. J Bone Miner Res. 2002;17(8):1486–1497
  10. Ruoslahti E, Pierschbacher MD. New perspectives in cell adhesion: RGD and integrins. Science. 1987;238:491–497
  11. Attur MG, Dave MN, Stuchin S, Kowalski AJ, Steiner G, Abramson SB, et al. Osteopontin: an intrinsic inhibitor of inflammation in cartilage. Arthritis Rheum. 2001;44:578–584
  12. Pullig O, Weseloh G, Gauer S, Swoboda B. Osteopontin is expressed by adult human osteoarthritic chondrocytes: protein and mRNA analysis of normal and osteoarthritic cartilage. Matrix Biol. 2000;19:245–255
  13. McKee MD, Glimcher MJ, Nanci A. High-resolution immunolocalization of osteopontin and osteocalcin in bone and cartilage during endochondral ossification in the chicken tibia. Anat Rec. 1992;234:479–492
  14. Daheshia M, Yao JQ. The interleukin 1beta pathway in the pathogenesis of osteoarthritis. J Rheumatol. 2008;35(12):2306–2312
  15. Presle N, Pottie P, Dumond H, Guillaume C, Lapicque F, Pallu S, et al. Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthritis Cartilage. 2006;14:690–695
  16. Andereya S, Streich N, Schmidt-Rohlfing B, Mumme T, Müller-Rath R, Schneider U. Comparison of modern marker proteins in serum and synovial fluid in patients with advanced osteoarthrosis and rheumatoid arthritis. Rheumatol Int. 2006;26:432–438
  17. Ohshima S, Yamaguchi N, Nishioka K, Mima T, Ishii T, Umeshita-Sasai M, et al. Enhanced local production of osteopontin in rheumatoid joints. J Rheumatol. 2002;29:2061–2067
  18. Petrow PK, Hummel KM, Schedel J, Franz JK, Klein CL, Müller-Ladner U, et al. Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts. Arthritis Rheum. 2000;43(7):1597–1605
  19. Kaneko S, Satoh T, Chiba J, Ju C, Inoue K, Kagawa J. Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis. Cytokines Cell Mol Ther. 2000;6:71–79
  20. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957;16:494–502
  21. van der Sluijs JA, Geesink RG, van der Linden AJ, Bulstra SK, Kuyer R, Drukker J. The reliability of the Mankin score for osteoarthritis. J Orthop Res. 1992;10(1):58–61
  22. Yagi R, McBurney D, Laverty D, Weiner S, Horton WE. Intrajoint comparisons of gene expression patterns in human osteoarthritis suggest a change in chondrocyte phenotype. J Orthop Res. 2005;23:1128–1138
  23. Xu G, Nie H, Li N, Zheng W, Zhang D, Feng G, et al. Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. J Clin Invest. 2005;115(4):1060–1067
  24. Chen YJ, Shen JL, Wu CY, Chang YT, Chen CM, Lee FY. Elevated plasma osteopontin level is associated with occurrence of psoriasis and is an unfavorable cardiovascular risk factor in patients with psoriasis. J Am Acad Dermatol. 2009;60(2):225–230
  25. Denhardt DT, Giachelli CM, Rittling SR. Role of osteopontin in cellular signaling and toxicant injury. Annu Rev Pharmacol Toxicol. 2001;41:723–749
  26. Ramaiah SK, Rittling S. Role of osteopontin in regulating hepatic inflammatory responses and toxic liver injury. Expert Opin Drug Metab Toxicol. 2007;3(4):519–526
  27. Kolb A, Kleeff J, Guweidhi A, Esposito I, Giese NA, Adwan H, et al. Osteopontin influences the invasiveness of pancreatic cancer cells and is increased in neoplastic and inflammatory conditions. Cancer Biol Ther. 2005;4(7):740–746
  28. Fedarko NS, Jain A, Karadag A, Van Eman MR, Fisher LW. Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer. Clin Cancer Res. 2001;7:4060–4066
  29. Song G, Cai QF, Mao YB, Ming YL, Bao SD, Ouyang GL. Osteopontin promotes ovarian cancer progression and cell survival and increases HIF-1alpha expression through the PI3-K/Akt pathway. Cancer Sci. 2008;99(10):1901–1907
  30. Yang GH, Fan J, Xu Y, Qiu SJ, Yang XR, Shi GM, et al. Osteopontin combined with CD44, a novel prognostic biomarker for patients with hepatocellular carcinoma undergoing curative resection. Oncologist. 2008;13(11):1155–1165
  31. Reiniger IW, Wolf A, Welge-Lüssen U, Mueller AJ, Kampik A, Schaller UC. Osteopontin as a serologic marker for metastatic uveal melanoma: results of a pilot study. Am J Ophthalmol. 2007;143:705–707

PII: S1063-4584(09)00208-8

doi: 10.1016/j.joca.2009.07.009

Osteoarthritis and Cartilage
Volume 18, Issue 1 , Pages 82-87 , January 2010