Osteoarthritis and Cartilage
Volume 15, Issue 1 , Pages 1-8 , January 2007

Evidence for functional ATP-sensitive (KATP) potassium channels in human and equine articular chondrocytes

  • A. Mobasheri, B.Sc., A.R.C.S. (Hons.), M.Sc., D.Phil. (Oxon.) (Associate Professor)

      Affiliations

    • Faculty of Veterinary Science, University of Liverpool, Liverpool L69 7ZJ, UK
    • Division of Comparative Medicine, The School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK
    • ,
  • T.C. Gent, B.Sc. (Hons.) (Research Student)

      Affiliations

    • Faculty of Veterinary Science, University of Liverpool, Liverpool L69 7ZJ, UK
    • ,
  • A.I. Nash, B.Sc. (Hons.) (Undergraduate Student)

      Affiliations

    • Faculty of Veterinary Science, University of Liverpool, Liverpool L69 7ZJ, UK
    • ,
  • M.D. Womack, B.Sc. (Hons.), Ph.D. (Hons.) (Research Fellow)

      Affiliations

    • Faculty of Veterinary Science, University of Liverpool, Liverpool L69 7ZJ, UK
    • ,
  • C.A. Moskaluk, M.D., Ph.D. (Associate Professor)

      Affiliations

    • Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, United States of America
    • Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908, United States of America
    • ,
  • R. Barrett-Jolley, B.Sc. (Hons.), D.Phil. (Oxon.) (Lecturer)

      Affiliations

    • Faculty of Veterinary Science, University of Liverpool, Liverpool L69 7ZJ, UK
    • Corresponding Author InformationAddress for correspondence and reprint requests to: Richard Barrett-Jolley, B.Sc. (Hons.), D.Phil. (Oxon.), Lecturer, Department of Veterinary Preclinical Sciences, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 7ZJ, UK. Tel: 44-151-794-4225; Fax: 44-151-794-4243.

Received 15 December 2005 ,Accepted 25 June 2006.

References 

  1. Schipani E, Ryan HE, Didrickson S, Kobayashi T, Knight M, Johnson RS. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev. 2001;15:2865–2876
  2. Coimbra IB, Jimenez SA, Hawkins DF, Piera-Velazquez S, Stokes DG. Hypoxia inducible factor-1 alpha expression in human normal and osteoarthritic chondrocytes. Osteoarthritis Cartilage. 2004;12:336–345
  3. Mobasheri A, Richardson S, Mobasheri R, Shakibaei M, Hoyland JA. Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes. Histol Histopathol. 2005;20:1327–1338
  4. Henrotin Y, Kurz B, Aigner T. Oxygen and reactive oxygen species in cartilage degradation: friends or foes?. Osteoarthritis Cartilage. 2005;13:643–654
  5. Edwards G, Weston AH. The role of potassium channels in excitable cells. Diabetes Res Clin Pract. 1995;28(Suppl):57–66
  6. Coetzee WA, Amarillo Y, Chiu J, Chow A, Lau D, McCormack T, et al. Molecular diversity of K+ channels. Ann N Y Acad Sci. 1999;868:233–285
  7. Christie MJ. Molecular and functional diversity of K+ channels. Clin Exp Pharmacol Physiol. 1995;22:944–951
  8. Babenko AP, Aguilar-Bryan L, Bryan J. A view of sur/KIR6.X, KATP channels. Annu Rev Physiol. 1998;60:667–687
  9. Minami K, Miki T, Kadowaki T, Seino S. Roles of ATP-sensitive K+ channels as metabolic sensors: studies of Kir6.x null mice. Diabetes. 2004;53(Suppl 3):176–180
  10. Quayle JM, Nelson MT, Standen NB. ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiol Rev. 1997;77:1165–1232
  11. Dart C, Standen NB. Hypoxia induces a potassium current in smooth-muscle cells isolated from the porcine coronary–artery. J Physiol (Lond). 1994;477P:85–86
  12. Phillis JW. Adenosine and adenine nucleotides as regulators of cerebral blood flow: roles of acidosis, cell swelling, and KATP channels. Crit Rev Neurobiol. 2004;16:237–270
  13. Mankin HJ, Dorfman H, Lippiell L, Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am. 1971;A 53:523–537
  14. Mobasheri A, Gent TC, Womack MD, Carter SD, Clegg PD, Barrett-Jolley R. Quantitative analysis of voltage-gated potassium currents from primary equine (Equus caballus) and elephant (Loxodonta africana) articular chondrocytes. Am J Physiol Regul Integr Comp Physiol. 2005;289:R172–R180
  15. Barrett-Jolley R, Davies NW. Kinetic analysis of the inhibitory effect of glibenclamide on KATP channels of mammalian skeletal muscle. J Membr Biol. 1997;155:257–262
  16. Krause E, Englert H, Gogelein H. Adenosine triphosphate-dependent K-currents activated by metabolic inhibition in rat ventricular myocytes differ from those elicited by the channel opener rilmakalim. Pflugers Arch. 1995;429:625–635
  17. Standen NB, Pettit AI, Davies NW, Stanfield PR. Activation of Atp-dependent K+ currents in intact skeletal-muscle fibers by reduced intracellular Ph. Proc R Soc Lond B Biol Sci. 1992;247:195–198
  18. Babenko AP, Bryan J. SUR-dependent modulation of KATP channels by an N-terminal KIR6.2 peptide. Defining intersubunit gating interactions. J Biol Chem. 2002;277:43997–44004
  19. Aguilar-Bryan L, Bryan J. Molecular biology of adenosine triphosphate-sensitive potassium channels. Endocr Rev. 1999;20:101–135
  20. Barrett-Jolley R, McPherson GA. Characterization of K(ATP) channels in intact mammalian skeletal muscle fibres. Br J Pharmacol. 1998;123:1103–1110
  21. Beech DJ, Zhang H, Nakao K, Bolton TB. K-channel activation by nucleotide diphosphates and its inhibition by glibenclamide in vascular smooth-muscle cells 1. Br J Pharmacol. 1993;110:573–582
  22. Ashcroft FM, Gribble FM. Correlating structure and function in ATP-sensitive K+ channels. Trends Neurosci. 1998;21:288–294

PII: S1063-4584(06)00205-6

doi: 10.1016/j.joca.2006.06.017

Osteoarthritis and Cartilage
Volume 15, Issue 1 , Pages 1-8 , January 2007

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