Next »
Osteoarthritis and Cartilage
Volume 18, Issue 3
, Pages 279-288
, March 2010
MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation – divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation
References
- . Structure and function of aggrecan. Cell Res. 2002 Mar;12(1):19–32
- Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature. 2005 Mar 31;434(7033):644–648
- Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. Arthritis Rheum. 2004 Aug;50(8):2547–2558
- . ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan. J Biol Chem. 2007 Mar 23;282(12):8632–8640
- ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature. 2005 Mar 31;434(7033):648–652
- Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants. J Biol Chem. 2000 Oct 20;275(42):33027–33037
- . Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain. FEBS Lett. 1998 Jul 3;430(3):186–190
- . Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent. J Clin Invest. 1996 Nov 15;98(10):2292–2299
- In vitro, ex vivo, and in vivo methodological approaches for studying therapeutic targets of osteoporosis and degenerative joint diseases: how biomarkers can assist?. Assay Drug Dev Technol. 2005 Oct;3(5):553–580
- Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation. Osteoarthritis Cartilage. 2006 Aug;14(8):738–748
- Effects of ovariectomy and estrogen therapy on type II collagen degradation and structural integrity of articular cartilage in rats: implications of the time of initiation. Arthritis Rheum. 2006 Aug;54(8):2441–2451
- Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase. Arthritis Rheum. 2000 Mar;43(3):664–672
- Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest. 1997 Apr 1;99(7):1534–1545
- . The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B. J Biol Chem. 1992 Sep 25;267(27):19470–19474
- MMP and non-MMP-mediated release of aggrecan and its fragments from articular cartilage: a comparative study of three different aggrecan and glycosaminoglycan assays. Osteoarthritis Cartilage. 2007 Feb;15(2):212–221
- Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation. Arthritis Rheum. 2007 May;56(5):1549–1558
- . Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity. Arthritis Res Ther. 2008;10(3):R63
- . Prospects for disease modification in osteoarthritis. Nat Clin Pract Rheumatol. 2006 Jun;2(6):304–312
- . Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum. 2001 Jun;44(6):1237–1247
- . Are cytokines involved in osteoarthritic pathophysiology?. Semin Arthritis Rheum. 1991 Jun;20(6 Suppl 2):12–25
- . The role of cytokines in osteoarthritis pathophysiology. Biorheology. 2002;39(1–2):237–246
- . Cytokine imbalance in the pathogenesis of rheumatoid arthritis: the role of interleukin-1 receptor antagonist. Semin Arthritis Rheum. 2001 Apr;30(5 Suppl 2):1–6
- . Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis. Arthritis Rheum. 1990 Mar;33(3):305–315
- The roles of MAPKs in disease. Cell Res. 2008 Apr;18(4):436–442
- . Transforming growth factor-beta-induced osteoblast elongation regulates osteoclastic bone resorption through a p38 mitogen-activated protein kinase- and matrix metalloproteinase-dependent pathway. J Biol Chem. 2001 Oct 19;276(42):39350–39358
- The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297–315
- Cartilage destruction in collagen induced arthritis assessed with a new biochemical marker for collagen type II C-telopeptide fragments. J Rheumatol. 2004 Jun;31(6):1174–1179
- Should subchondral bone turnover be targeted when treating osteoarthritis?. Osteoarthritis Cartilage. 2008 Jun;16(6):638–646
- Characterization of metalloprotease cleavage products of human articular cartilage. Arthritis Rheum. 2008 Aug;58(8):2420–2431
- Anabolic and catabolic function of chondrocyte ex vivo is reflected by the metabolic processing of type II collagen. Osteoarthritis Cartilage. 2007 Mar;15(3):335–342
- . The type II collagen fragments Helix-II and CTX-II reveal different enzymatic pathways of human cartilage collagen degradation. Osteoarthritis Cartilage. 2008 Oct;16(10):1183–1191
- Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways. Proc Natl Acad Sci USA. 2007 Oct 23;104(43):16898–16903
- . Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4). Matrix Biol. 2002 Oct;21(6):499–511
- . Oncostatin M in combination with tumor necrosis factor alpha induces cartilage damage and matrix metalloproteinase expression in vitro and in vivo. Arthritis Rheum. 2003 Dec;48(12):3404–3418
- . An odyssey from breast to bone: multi-step control of mammary metastases and osteolysis by matrix metalloproteinases. APMIS. 1999 Jan;107:128–136
- Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. J Biol Chem. 2002 Nov 15;277(46):44061–44067
- Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes. Exp Cell Res. 2003 Aug 1;288(1):208–217
- . Alpha-MSH inhibits TNF-alpha-induced matrix metalloproteinase-13 expression by modulating p38 kinase and nuclear factor kappaB signaling in human chondrosarcoma HTB-94 cells. Osteoarthritis Cartilage. 2008 Jan;16(1):115–124
- . Effects of intra-articular injection of p38 mitogen-activated protein kinase inhibitor on matrix metalloproteinase in articular cartilage of a rat model of osteoarthritis. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007 Dec;29(6):777–781
- Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels. J Immunol. 1997 Apr 1;158(7):3165–3173
- . Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum. 2000 Apr;43(4):801–811
- . Signaling pathways implicated in oncostatin M-induced aggrecanase-1 and matrix metalloproteinase-13 expression in human articular chondrocytes. Biochim Biophys Acta. 2007 Mar;1773(3):309–320
- . Role of Src signal transduction pathways in scatter factor-mediated cellular protection. J Biol Chem. 2009 Mar 20;284(12):7561–7577
- Transforming growth factor beta1 induces alphavbeta3 integrin expression in human lung fibroblasts via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway. J Biol Chem. 2008 May 9;283(19):12898–12908
PII: S1063-4584(09)00297-0
doi: 10.1016/j.joca.2009.11.005
© 2009 Osteoarthritis Research Society International. Published by Elsevier Inc. All rights reserved.
Next »
Osteoarthritis and Cartilage
Volume 18, Issue 3
, Pages 279-288
, March 2010
