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Consistency of knee pain: correlates and association with function
11 August 2010
T. Neogi, M.C. Nevitt, M. Yang, J.R. Curtis, J. Torner, D.T. Felson
Summary: Objective: The extent and factors associated with knee pain fluctuation are not well-known. We evaluated the prevalence, correlates, and association with function of consistency of knee pain....
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Adult bone marrow stromal cell-based tissue-engineered aggrecan exhibits ultrastructure and nanomechanical properties superior to native cartilage
09 August 2010
H.-Y. Lee, P.W. Kopesky, A. Plaas, J. Sandy, J. Kisiday, D. Frisbie, A.J. Grodzinsky, C. Ortiz
Summary: Objective: To quantify the structural characteristics and nanomechanical properties of aggrecan produced by adult bone marrow stromal cells (BMSCs) in peptide hydrogel scaffolds and compare t...
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Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis
09 August 2010
J.J. McDougall, N. Schuelert, J. Bowyer
Summary: Cathepsin K is a cysteine proteinase which is believed to contribute to osteoarthritis (OA) pathogenesis. This brief report evaluates the effect of the novel selective cathepsin K inhibitor A...
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Association of single-nucleotide polymorphisms in HLA class II/III region with knee osteoarthritis
06 August 2010
D. Shi, Q. Zheng, D. Chen, L. Zhu, A. Qin, J. Fan, J. Liao, Z. Xu, Z. Lin, P. Normal, J. Xu, T. Nakamura, K. Dai, M. Zheng, Q. Jiang
Summary: Objective: A genome-wide association study and a replication using Japanese, Spanish and Greek Caucasian populations have recently indicated two single-nucleotide polymorphisms (SNPs) (rs7775...
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Reference values and Z-scores for subregional femorotibial cartilage thickness – results from a large population-based sample (Framingham) and comparison with the non-exposed Osteoarthritis Initiative reference cohort
06 August 2010
F. Eckstein, M. Yang, A. Guermazi, F.W. Roemer, M. Hudelmaier, K. Picha, F. Baribaud, W. Wirth, D.T. Felson
Summary: Objective: To establish sex-specific (subregional) reference values of cartilage thickness and potential maximal Z-scores in the femorotibial joint. Methods: The mean cartilage thickness (ThC...
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